NDLI: Prp40 and early events in splice site definition.

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Prp40 and early events in splice site definition.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Becerra, Soraya Andrés-León, Eduardo Prieto-Sánchez, Silvia Hernández-Munain, Cristina Suñé, Carlos
Description	Country affiliation: Spain Author Affiliation: Becerra S ( Department of Molecular Biology, Instituto de Parasitología y Biomedicina 'López Neyra', Consejo Superior de Investigaciones Científicas (IPBLN-CSIC), PTS Granada 18016, Spain.); Andrés-León E ( Bioinformatics Unit, Instituto de Parasitología y Biomedicina 'López Neyra', Consejo Superior de Investigaciones Científicas (IPBLN-CSIC), PTS Granada 18016, Spain.); Prieto-Sánchez S ( Department of Molecular Biology, Instituto de Parasitología y Biomedicina 'López Neyra', Consejo Superior de Investigaciones Científicas (IPBLN-CSIC), PTS Granada 18016, Spain.); Hernández-Munain C ( Department of Cell Biology and Immunology, Instituto de Parasitología y Biomedicina 'López Neyra', Consejo Superior de Investigaciones Científicas (IPBLN-CSIC), PTS Granada 18016, Spain.); Suñé C ( Department of Molecular Biology, Instituto de Parasitología y Biomedicina 'López Neyra', Consejo Superior de Investigaciones Científicas (IPBLN-CSIC), PTS Granada 18016, Spain.)
Abstract	The alternative splicing (AS) of precursor messenger RNA (pre-mRNA) is a tightly regulated process through which introns are removed to leave the resulting exons in the mRNA appropriately aligned and ligated. The AS of pre-mRNA is a key mechanism for increasing the complexity of proteins encoded in the genome. In humans, more than 90% of genes undergo AS, underscoring the importance of this process in RNA biogenesis. As such, AS misregulation underlies multiple human diseases. The splicing reaction is catalyzed by the spliceosome, a highly dynamic complex that assembles at or near the intron/exon boundaries and undergoes sequential conformational and compositional changes during splicing. The initial recognition of splice sites defines the exons that are going to be removed, which is a critical step in the highly regulated splicing process. Although the available lines of evidence are increasing, the molecular mechanisms governing AS, including the initial interactions occurring at intron/exon boundaries, and the factors that modulate these critical connections by functioning as a scaffold for active-site RNAs or proteins, remain poorly understood. In this review, we summarize the major hallmarks of the initial steps in the splicing process and the role of auxiliary factors that contribute to the assembly of the spliceosomal complex. We also discuss the role of the essential yeast Prp40 protein and its mammalian homologs in the specificity of this pre-mRNA processing event. In addition, we provide the first exhaustive phylogenetic analysis of the molecular evolution of Prp40 family members. WIREs RNA 2016, 7:17-32. doi: 10.1002/wrna.1312 For further resources related to this article, please visit the WIREs website.
File Format	HTM / HTML
ISSN	17577004
Issue Number	1
Volume Number	7
e-ISSN	17577012
Journal	Wiley Interdisciplinary Reviews: RNA
Language	English
Publisher	Wiley
Publisher Date	2016-01-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Molecular Biology Alternative Splicing Carrier Proteins Genetics Ribonucleoprotein, U1 Small Nuclear Saccharomyces Cerevisiae Proteins Evolution, Molecular Exons Humans Introns Protein Structure, Tertiary Spliceosomes Journal Article Research Support, Non-u.s. Gov't Review
Content Type	Text
Resource Type	Article
Subject	Molecular Biology Biochemistry

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