NDLI: Exon and intron definition in pre-mRNA splicing.

Please wait, while we are loading the content...

Year: 2016 Volume: 7

Year: 2015 Volume: 6

Year: 2014 Volume: 5

Year: 2013 Volume: 4

Year: 2013 Volume: 4 Issue: 6

Year: 2013 Volume: 4 Issue: 5

Year: 2013 Volume: 4 Issue: 4

Year: 2013 Volume: 4 Issue: 3

Year: 2013 Volume: 4 Issue: 2

Year: 2013 Volume: 4 Issue: 1

The CTD code of RNA polymerase II: a structural view.

Cajal bodies: where form meets function.

Exon and intron definition in pre-mRNA splicing.

The significant other: splicing by the minor spliceosome.

Connections between chromatin signatures and splicing.

Whence genes in pieces: reconstruction of the exon-intron gene structures of the last eukaryotic common ancestor and other ancestral eukaryotes.

Transfer RNA modifications: nature's combinatorial chemistry playground.

Long non-coding RNAs in stem cell pluripotency.

Computational biology of RNA interactions.

The curious case of miRNAs in circulation: potential diagnostic biomarkers?

Year: 2012 Volume: 3

Year: 2011 Volume: 2

Year: 2010 Volume: 1

Exon and intron definition in pre-mRNA splicing.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	De Conti, Laura Baralle, Marco Buratti, Emanuele
Description	Country affiliation: Italy Author Affiliation: De Conti L ( International Centre for Genetic Engineering and Biotechnology, Trieste, Italy.)
Abstract	One of the fundamental issues in RNA splicing research is represented by understanding how the spliceosome can successfully define exons and introns in a huge variety of pre-mRNA molecules with nucleotide-precision. Since its first description, researchers in this field have identified and characterized many fundamental elements and players capable of affecting the splicing process, both in a negative and positive manner. Indeed, it can be argued that today we know a great deal about the forces that make an exon, an exon and an intron, an intron. As will be discussed in this review, these decisions are a result of a complex combinatorial control resulting from many different factors/influences. Most importantly, these influences act across several levels of complexity starting from the relatively simple interaction between two consensus 5' and 3' splice sites to much more complex factors: such as the interplay between silencer or enhancer sequences, transcriptional processivity, genomic milieu, nucleosome positioning, and histone modifications at the chromatin level. Depending on local contexts, all these factors will act either antagonistically or synergistically to decide the exon/intron fate of any given RNA sequence. At present, however, what we still lack is a precise understanding of how all these processes add up to help the spliceosome reach a decision. Therefore, it is expected that future challenges in splicing research will be the careful characterization of all these influences to improve our ability to predict splicing choices in different organisms or in specific contexts.
File Format	HTM / HTML
ISSN	17577004
Issue Number	1
Volume Number	4
e-ISSN	17577012
Journal	Wiley Interdisciplinary Reviews: RNA
Language	English
Publisher	Wiley
Publisher Date	2013-01-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Molecular Biology Alternative Splicing Exons Introns Rna Splice Sites Rna Splicing Rna, Messenger Genetics Metabolism Enhancer Elements, Genetic Humans Rna Precursors Silencer Elements, Transcriptional Spliceosomes Journal Article Review
Content Type	Text
Resource Type	Article
Subject	Molecular Biology Biochemistry

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in