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Suboptimal vitamin K status despite supplementation in children and young adults with cystic fibrosis.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Dougherty, Kelly A. Schall, Joan I. Stallings, Virginia A.
Description	Country affiliation: United States Author Affiliation: Dougherty KA ( Department of Pediatrics, Children's Hospital of Philadelphia, PA 19104, USA. doughertyk@email.chop.edu)
Abstract	BACKGROUND: For children and adolescents with cystic fibrosis (CF) and pancreatic insufficiency, the efficacy of routine vitamin K supplementation to normalize vitamin K status remains unclear. OBJECTIVE: This study examined and determined predictors of vitamin K status in subjects aged 8-25 y with CF and pancreatic insufficiency taking various vitamin K supplements. DESIGN: In 97 subjects, serum 25-hydroxyvitamin D [25(OH)D], dietary intake, vitamin K supplement intake, and vitamin K statusmdashdetermined on the basis of the percentage of serum undercarboxylated osteocalcin (%ucOC; sufficient: lt 20%) and plasma proteins induced by vitamin K absence-factor II (PIVKA-II; n = 60; sufficient: le 2 microg/L)mdashwere assessed. The vitamin K supplementation groups were as follows: lt 150 microg/d (low; multivitamins or no supplement), 150-999 microg/d (middle; CF-specific vitamins), and ge 1000 microg/d (high; mephyton). %ucOC values were compared with 140 healthy subjects aged 6-21 y. RESULTS: In subjects with CF, the median (range) %ucOC was 35% (3%, 76%) and the median (range) for PIVKA-II was 2 (0, 42) micro g/L. Subjects with CF had a higher %ucOC with low [45% (10%, 76%)] and medium [41% (3%, 66%)] supplement intakes but not with a high supplement intake [16% (4%, 72%)] compared with healthy subjects [23% (0%, 43%); both P lt 0.05]. Supplementation group for males and females and 25(OH)D and age for males were significant predictors of vitamin K status. CONCLUSIONS: Vitamin K status was often suboptimal despite routine supplementation. Only subjects taking high-dose vitamin K achieved a status similar to healthy subjects, and only the vitamin K supplementation dose predicted vitamin K status for males and females. These data suggest that higher doses of vitamin K are required.
File Format	HTM / HTML
ISSN	00029165
e-ISSN	19383207
DOI	10.3945/ajcn.2010.29350
Journal	American Journal of Clinical Nutrition
Issue Number	3
Volume Number	92
Language	English
Publisher	American Society for Nutrition
Publisher Date	2010-09-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Nutritional Sciences Cystic Fibrosis Drug Therapy Nutritional Status Pancreatic Diseases Vitamin K Deficiency Vitamin K Therapeutic Use Vitamins Adolescent Case-control Studies Blood Complications Dietary Supplements Osteocalcin Prothrombin Metabolism Sex Factors Vitamin D Analogs & Derivatives Administration & Dosage Etiology Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Nutrition and Dietetics Medicine

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