NDLI: Dissociated learning using GABAergic drugs.

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Dissociated learning using GABAergic drugs.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Azarashvili, A. A. Kaimachnikova, I. E.
Description	Country affiliation: RUSSIA Author Affiliation: Azarashvili AA ( Laboratory for Biological System Energetics, Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Russia. azarashvili@rambler.ru)
Abstract	Experiments on Wistar rats addressed the possibility of dissociated learning using drugs acting directly on brain GABA(B) receptors. A previously suggested hypothesis was tested: that the cholinergic system of the brain plays the decisive role in the mechanisms of dissociative learning. The data obtained here provided evidence that dissociated learning an occur with compounds acting on the GABAergic transmitter system of the brain. Dissociated states arose on treatment of animals with both the GABA-mimetic baclofen and the GABA receptor antagonist 5-aminovaleric acid. Thus, these results show that dissociated learning can occur using drugs acting on both the cholinergic and the GABAergic transmitter systems of the brain.
File Format	HTM / HTML
ISSN	00970549
Issue Number	2
Volume Number	39
e-ISSN	1573899X
Journal	Neuroscience and Behavioral Physiology
Language	English
Publisher	Springer
Publisher Date	2009-02-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Behavioral Sciences Discipline Neurology Amino Acids, Neutral Pharmacology Baclofen Conditioning, Classical Drug Effects Learning Physiology Receptors, Gaba-b Animals Gaba-b Receptor Agonists Gaba-b Receptor Antagonists Male Rats Rats, Wistar Journal Article
Content Type	Text
Resource Type	Article
Subject	Neuroscience

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