NDLI: Role of nephrin in podocyte injury induced by angiotension II.

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Role of nephrin in podocyte injury induced by angiotension II.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Yu, Shengyou
Description	Country affiliation: China Author Affiliation: Yu S ( a Guangzhou Medical University, Guangzhou First People's Hospital , Guangdong Province , China.)
Abstract	OBJECTIVE: To investigate the function of nephrin in podocytes and its relation to proteinuria in kidney diseases, and to study more clearly theoretical basis for the molecular mechanism of losartan anti-proteinuria and the special beneficial effects of losartan on podocyte injury. METHODS: Experiment set up control, Ang II and losartan group. Cell morphology was observed perturbation, and using image processing software to analyze the cell body of cell morphology and size of the difference after 8 h, 24 h and 48 h. Detecting nephrin mRNA and protein expression changes by real time PCR (RT-PCR) and western blotting at different time points. RESULTS: Podocyte cell bodies were significantly reduced after Ang II injury (p < 0.01), losartan directly reduces the rate of apoptotic podocytes induced by Ang. Apoptotic podocytes may related to the decrease of nephrin mRNA and protein expressions, losartan reduced the apoptosis and proteinuria by declining nephrin mRNA and protein expressions. CONCLUSION: Ang II induced podocyte injury caused abnormal expression and distribution of nephrin in podocytes, losartan maybe maintain the stability of nephrin expression and the integrity of hole diaphragm (SD) structure and function by blocking the signal path, playing a important role in protection mechanisms of anti-proteinuria. Our findings provide some possible clues for further exploring the pharmacological targets to the proteinuria. These novel findings provide new insights into the beneficial effects of losartan on podocytes directly.
File Format	HTM / HTML
ISSN	10799893
Issue Number	1
Volume Number	36
e-ISSN	15324281
Journal	Journal of Receptors and Signal Transduction
Language	English
Publisher	Taylor & Francis
Publisher Date	2016-01-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Cell Biology Discipline Physiology Discipline Biochemistry Angiotensin Ii Adverse Effects Apoptosis Drug Effects Kidney Glomerulus Pathology Losartan Pharmacology Membrane Proteins Metabolism Podocytes Vasoconstrictor Agents Anti-arrhythmia Agents Blotting, Western Cell Proliferation Cells, Cultured Humans Kidney Diseases Etiology Prevention & Control Genetics Rna, Messenger Real-time Polymerase Chain Reaction Reverse Transcriptase Polymerase Chain Reaction Journal Article
Content Type	Text
Resource Type	Article
Subject	Cell Biology Biochemistry Molecular Biology

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