NDLI: Effect of the TLR2/MyD88/NF-κB axis on corneal allograft rejection after penetrating keratoplasty.

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Effect of the TLR2/MyD88/NF-κB axis on corneal allograft rejection after penetrating keratoplasty.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Wu, Wei Yu, Shengyou Feng, Songfu Yang, Jize Lu, Xiaohe
Description	Author Affiliation: Wu W ( a Department of Ophthalmology , ZhuJiang Hospital of Southern Medical University , Guangzhou 510282 , Guangdong Province , China and.); Yu S ( b Department of pediatrics , Guangzhou first people's Hospital , Guangzhou 510282 , Guangdong Province , China.); Feng S ( a Department of Ophthalmology , ZhuJiang Hospital of Southern Medical University , Guangzhou 510282 , Guangdong Province , China and.); Yang J ( a Department of Ophthalmology , ZhuJiang Hospital of Southern Medical University , Guangzhou 510282 , Guangdong Province , China and.); Lu X ( a Department of Ophthalmology , ZhuJiang Hospital of Southern Medical University , Guangzhou 510282 , Guangdong Province , China and.)
Abstract	PURPOSE: To evaluate the effect of the TLR2 (Toll-like receptor 2)/MyD88/NF-κB axis on the allograft rejection after penetrating keratoplasty (PK). METHODS: The PK rat models were randomly divided into four groups: allograft group, dexamethasone group, PDTC group and isograft group. The mean survival time (MST) and rejection index of corneal grafts were observed. The immunohistochemical staining of TGF- was performed on day 15. The messenger RNA (mRNA) and protein expression of TLR2, MyD88 and NF-κB p65 in corneal grafts were detected by reverse transcription-polymerase chain reaction (RT-PCR) and western blotting. RESULTS: On days 5, 7, 9, 11, 13 and 15, the rejection index in the allograft group was higher than in the other three groups (p < 0.05). The MST in the PDTC group (MST, 23.30 ± 0.42 days, n = 10) and in the dexamethasone group (MST, 24.40 ± 0.50 days, n = 10) were higher than in the allograft group (MST, 14.7 ± 0.70 days, n = 10) (χ(2) = 18.02, p < 0.01; χ(2) = 21.47, p < 0.01). The expression of TNF- in the PDTC group and in the dexamethasone group decreased compared with the allograft group by immunohistochemistry. On day 15, the mRNA and protein expression of TLR2, MyD88 and NF-κB p65 in the PDTC group and the dexamethasone group were less than in the allograft group (p < 0.05). CONCLUSIONS: Expression of TLR2, MyD88 and NF-κB p65 in rat corneal graft increased significantly and concurred with the allograft rejection, but were effectively inhibited by the treatment with dexamethasone and PDTC after PK. Dexamethasone could improve corneal allograft survival by the TLR2/MyD88/NF-κB axis. PDTC could suppress corneal graft rejection by inhibiting the activity of NF-κB. The TLR2/MyD88/NF-κB axis maybe a potential therapeutic target for corneal allograft rejection.
File Format	HTM / HTML
ISSN	10799893
Issue Number	1
Volume Number	36
e-ISSN	15324281
Journal	Journal of Receptors and Signal Transduction
Language	English
Publisher	Taylor & Francis
Publisher Date	2016-01-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Cell Biology Discipline Physiology Discipline Biochemistry Antioxidants Pharmacology Glucocorticoids Graft Rejection Prevention & Control Keratoplasty, Penetrating Myeloid Differentiation Factor 88 Genetics Nf-kappa B Toll-like Receptor 2 Allografts Animals Blotting, Western Cells, Cultured Dexamethasone Gene Expression Regulation Physiology Metabolism Immunoenzyme Techniques Male Postoperative Complications Proline Analogs & Derivatives Rna, Messenger Rats Rats, Sprague-dawley Rats, Wistar Real-time Polymerase Chain Reaction Reverse Transcriptase Polymerase Chain Reaction Thiocarbamates Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Cell Biology Biochemistry Molecular Biology

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