NDLI: In Vitro Inhibition of 4-Nitroquinoline-1-Oxide Genotoxicity by Probiotic Lactobacillus rhamnosus IMC501.

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In Vitro Inhibition of 4-Nitroquinoline-1-Oxide Genotoxicity by Probiotic Lactobacillus rhamnosus IMC501.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Bocci, Alessandro Sebastiani, Bartolomeo Trotta, Francesca Federici, Ermanno Cenci, Giovanni
Description	Country affiliation: Italy Author Affiliation: Bocci A ( Department of Chemistry, Biology and Biotechnology, University of Perugia, Via del Giochetto, I-06122 Perugia, Italy.); Sebastiani B ( Department of Chemistry, Biology and Biotechnology, University of Perugia, Via del Giochetto, I-06122 Perugia, Italy.); Trotta F ( Department of Chemistry, Biology and Biotechnology, University of Perugia, Via del Giochetto, I-06122 Perugia, Italy.); Federici E ( Department of Chemistry, Biology and Biotechnology, University of Perugia, Via del Giochetto, I-06122 Perugia, Italy.); Cenci G ( Department of Chemistry, Biology and Biotechnology, University of Perugia, Via del Giochetto, I-06122 Perugia, Italy.)
Abstract	Inhibition of 4-nitroquinoline-1-oxide (4-NQO) genotoxicity by a probiotic strain of Lactobacillus rhamnosus (IMC501) was assessed by the prokaryotic short-term bioassay SOSChromotest, using Escherichia coli PQ37 as the target organism. Results showed the ability of strain IMC501 to rapidly and markedly counteract, in vitro, the DNA damage originated by the considered genotoxin. The inhibition was associated with a spectroscopic hypsochromic shift of the original 4-NQO profile and progressive absorbance increase of a new peak. IR-Raman and GC-MS analyses confirmed the disappearance of 4-NQO after contact with the microorganism, showing also the absence of any genotoxic molecule potentially available for metabolic activation (i.e., 4-hydroxyaminoquinoline-1-oxide and 4-nitrosoquinoline-1-oxide). Furthermore, we have shown the presence of the phenyl-quinoline and its isomers as major non-genotoxic conversion products, which led to the hypothesis of a possible pattern of molecular transformation. These findings increase knowledge on lactobacilli physiology and contribute to the further consideration of antigenotoxicity as a nonconventional functional property of particular probiotic strains.
File Format	HTM / HTML
ISSN	10177825
e-ISSN	17388872
Journal	Journal of Microbiology and Biotechnology
Issue Number	10
Volume Number	25
Language	English
Publisher	Korean Society for Microbiology and Biotechnology
Publisher Date	2015-10-01
Publisher Place	Korea (South)
Access Restriction	Open
Subject Keyword	Discipline Microbiology Discipline Biotechnology 4-nitroquinoline-1-oxide Metabolism Toxicity Lactobacillus Rhamnosus Mutagens Probiotics Biological Assay Biotransformation Escherichia Coli Drug Effects Gas Chromatography-mass Spectrometry Sos Response (genetics) Spectrum Analysis, Raman
Content Type	Text
Resource Type	Article
Subject	Medicine Applied Microbiology and Biotechnology Biotechnology

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