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Structural and Functional Insight into Proliferating Cell Nuclear Antigen.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Park, So Young Jeong, Mi Suk Han, Chang Woo Yu, Hak Sun Jang, Se Bok
Description	Author Affiliation: Park SY ( Department of Molecular Biology, College of Natural Sciences, Pusan National University, Busan 46241, Republic of Korea.); Jeong MS ( Department of Parasitology, School of Medicine, Pusan National University, Yangsan 50612, Republic of Korea.); Han CW ( Department of Molecular Biology, College of Natural Sciences, Pusan National University, Busan 46241, Republic of Korea.); Yu HS ( Department of Molecular Biology, College of Natural Sciences, Pusan National University, Busan 46241, Republic of Korea.); Jang SB ( Department of Parasitology, School of Medicine, Pusan National University, Yangsan 50612, Republic of Korea.)
Abstract	Proliferating cell nuclear antigen (PCNA) is a critical eukaryotic replication accessory factor that supports DNA binding in DNA processing, such as DNA replication, repair, and recombination. PCNA consists of three toroidal-shaped monomers that encircle doublestranded DNA. The diverse functions of PCNA may be regulated by its interactions with partner proteins. Many of the PCNA partner proteins generally have a conserved PCNAinteracting peptide (PIP) motif, located at the N- or C- terminal region. The PIP motif forms a 310 helix that enters into the hydrophobic groove produced by an interdomain-connecting loop, a central loop, and a C-terminal tail in the PCNA. Post-translational modification of PCNA also plays a critical role in regulation of its function and binding partner proteins. Structural and biochemical studies of PCNA-protein will be useful in designing therapeutic agents, as well as estimating the outcome of anticancer drug development. This review summarizes the characterization of eukaryotic PCNA in relation to the protein structures, functions, and modifications, and interaction with proteins.
File Format	HTM / HTML
ISSN	10177825
e-ISSN	17388872
Journal	Journal of Microbiology and Biotechnology
Issue Number	4
Volume Number	26
Language	English
Publisher	Korean Society for Microbiology and Biotechnology
Publisher Date	2016-04-28
Publisher Place	Korea (South)
Access Restriction	Open
Subject Keyword	Discipline Microbiology Discipline Biotechnology
Content Type	Text
Resource Type	Article
Subject	Medicine Applied Microbiology and Biotechnology Biotechnology

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