NDLI: Suppression in Bitterness Intensity of Bitter Basic Drug by Chlorogenic Acid.

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Year: 2017 Volume: 65

Year: 2017 Volume: 65 Issue: 3

Year: 2017 Volume: 65 Issue: 2

Taste-Masking Effect of Chlorogenic Acid (CGA) on Bitter Drugs Evaluated by Taste Sensor and Surface Plasmon Resonance on the Basis of CGA-Drug Interactions.

Molecular Interaction between Intercellular Lipids in the Stratum Corneum and l-Menthol, as Analyzed by Synchrotron X-Ray Diffraction.

Suppression in Bitterness Intensity of Bitter Basic Drug by Chlorogenic Acid.

Design of Highly Dispersible PLGA Microparticles in Aqueous Fluid for the Development of Long-Acting Release Injectables.

Study of Schiff-Base-Derived with Dioxygenated Rings and Nitrogen Heterocycle as Potential ß-Ketoacyl-acyl Carrier Protein Synthase III (FabH) Inhibitors.

Synthesis of Linezolid Metabolites PNU-142300 and PNU-142586 toward the Exploration of Metabolite-Related Events.

Effects of MßCD on Lipoxygenase-Induced LDL Oxidation.

Year: 2017 Volume: 65 Issue: 1

Year: 2016 Volume: 64

Year: 2015 Volume: 63

Year: 2014 Volume: 62

Year: 2010 Volume: 58

Suppression in Bitterness Intensity of Bitter Basic Drug by Chlorogenic Acid.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Shiraishi, Sayuko Haraguchi, Tamami Nakamura, Saki Kojima, Honami Kawasaki, Ikuo Yoshida, Miyako Uchida, Takahiro
Description	Author Affiliation: Shiraishi S ( School of Pharmaceutical Sciences, Mukogawa Women's University.)
Abstract	The purpose of the study was to evaluate suppression of the bitterness intensity of bitter basic drugs by chlorogenic acid (CGA) using the artificial taste sensor and human gustatory sensation testing and to investigate the mechanism underlying bitterness suppression using H-NMR. Diphenhydramine hydrocholoride (DPH) was the bitter basic drug used in the study. Quinic acid (QNA) and caffeic acid (CFA) together form CGA. Although all three acids suppressed the bitterness intensity of DPH in a dose-dependent manner as determined by the taste sensor and in gustatory sensation tests, CFA was less effective than either CGA or QNA. Data from H-NMR spectroscopic analysis of mixtures of the three acids with DPH suggest that the carboxyl group, which is present in both QNA and CGA but not CFA, interact with the amine group of DPH. This study showed that the bitterness intensity of DPH was suppressed by QNA and CGA through a direct electrostatic interaction with DPH as confirmed in H-NMR spectroscopic analysis. CGA and QNA may therefore be useful bitterness-masking agents for the basic drug DPH.
File Format	HTM / HTML
ISSN	00092363
e-ISSN	13475223
Journal	Chemical and Pharmaceutical Bulletin
Issue Number	2
Volume Number	65
Language	English
Publisher	The Pharmaceutical Society of Japan
Publisher Date	2017-01-01
Publisher Place	Japan
Access Restriction	Open
Subject Keyword	Discipline Pharmacology Chlorogenic Acid Pharmacology Taste Perception Drug Effects Taste Caffeic Acids Chemistry Diphenhydramine Dose-response Relationship, Drug Drug Interactions Proton Magnetic Resonance Spectroscopy Quinic Acid
Content Type	Text
Resource Type	Article
Subject	Chemistry Medicine Drug Discovery

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