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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Cinkilic, Nilufer Cetintas, Sibel Kahraman Zorlu, Tolga Vatan, Ozgur Yilmaz, Dilek Cavas, Tolga Tunc, Sema Ozkan, Lutfi Bilaloglu, Rahmi |
| Description | Country affiliation: Turkey Author Affiliation: Cinkilic N ( Uludag University, Faculty of Arts and Sciences, Department of Biology, Cell Culture and Genetic Toxicology Laboratory, Bursa, Turkey. aydemirn@uludag.edu.tr) |
| Abstract | The present study was designed to determine the radioprotective effect of two phytochemicals, namely, quinic acid and chlorogenic acid, against X-ray irradiation-induced genomic instability in non-tumorigenic human blood lymphocytes. The protective ability of two phenolic acids against radiation-induced DNA damage was assessed using the alkaline comet assay in human blood lymphocytes isolated from two healthy human donors. A Siemens Mevatron MD2 (Siemens AG, USA, 1994) linear accelerator was used for irradiation. The results of the alkaline comet assay revealed that quinic acid and chlorogenic acid decreased the DNA damage induced by X-ray irradiation and provided a significant radioprotective effect. Quinic acid decreased the presence of irradiation-induced DNA damage by 5.99-53.57% and chlorogenic acid by 4.49-48.15%, as determined by the alkaline comet assay. The results show that quinic acid and chlorogenic acid may act as radioprotective compounds. Future studies should focus on determining the mechanism by which these phenolic acids provide radioprotection. |
| File Format | HTM / HTML |
| ISSN | 02786915 |
| Volume Number | 53 |
| e-ISSN | 18736351 |
| Journal | Food and Chemical Toxicology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2013-03-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Toxicology__semicolon__nutritional Discipline Sciences Chlorogenic Acid Pharmacology Dna Damage Drug Effects Quinic Acid Radiation-protective Agents X-rays Adverse Effects Adult Comet Assay Dose-response Relationship, Drug Dose-response Relationship, Radiation Female Humans Lymphocytes Radiation Effects Male Young Adult Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Toxicology Food Science |
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