NDLI: Molecular Interaction between Intercellular Lipids in the Stratum Corneum and l-Menthol, as Analyzed by Synchrotron X-Ray Diffraction.

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Year: 2017 Volume: 65

Year: 2017 Volume: 65 Issue: 3

Year: 2017 Volume: 65 Issue: 2

Taste-Masking Effect of Chlorogenic Acid (CGA) on Bitter Drugs Evaluated by Taste Sensor and Surface Plasmon Resonance on the Basis of CGA-Drug Interactions.

Molecular Interaction between Intercellular Lipids in the Stratum Corneum and l-Menthol, as Analyzed by Synchrotron X-Ray Diffraction.

Suppression in Bitterness Intensity of Bitter Basic Drug by Chlorogenic Acid.

Design of Highly Dispersible PLGA Microparticles in Aqueous Fluid for the Development of Long-Acting Release Injectables.

Study of Schiff-Base-Derived with Dioxygenated Rings and Nitrogen Heterocycle as Potential ß-Ketoacyl-acyl Carrier Protein Synthase III (FabH) Inhibitors.

Synthesis of Linezolid Metabolites PNU-142300 and PNU-142586 toward the Exploration of Metabolite-Related Events.

Effects of MßCD on Lipoxygenase-Induced LDL Oxidation.

Year: 2017 Volume: 65 Issue: 1

Year: 2016 Volume: 64

Year: 2015 Volume: 63

Year: 2014 Volume: 62

Year: 2010 Volume: 58

Molecular Interaction between Intercellular Lipids in the Stratum Corneum and l-Menthol, as Analyzed by Synchrotron X-Ray Diffraction.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Yoshida, Shinya Obata, Yasuko Onuki, Yoshinori Utsumi, Shunichi Ohta, Noboru Takahashi, Hiroshi Takayama, Kozo
Description	Author Affiliation: Yoshida S ( Department of Pharmaceutics, Hoshi University.)
Abstract	l-Menthol increases drug partitioning on the surface of skin, diffusion of drugs in the skin, and lipid fluidity in the stratum corneum and alters the rigidly arranged lipid structure of intercellular lipids. However, l-menthol is a solid at room temperature, and it is difficult to determine the effects of l-menthol alone. In this study, we vaporized l-menthol in order to avoid the effects of solvents. The vaporized l-menthol was applied to the stratum corneum or lipid models comprising composed of ceramides (CER) [EOS], the longest lipid acyl chain of the ceramides in the stratum corneum lipids that is associated with the barrier function of the skin; CER [NS], the shorter lipid acyl chain of the ceramides, and the most components in the stratum corneum of the intercellular lipids that is associated with water retention in the intercellular lipid structure of the stratum corneum; cholesterol; and palmitic acid. Synchrotron X-ray diffraction, differential scanning calorimetry, and attenuated total reflection Fourier transform infrared spectroscopy analyses revealed that the lipid models were composed of hexagonal packing and orthorhombic packing structures of different lamellar periods. Taken together, our results revealed that l-menthol strongly affected the lipid model composed of CER [EOS]. Therefore, l-menthol facilitated the permeation of drugs through the skin by liquid crystallization of the longer lamellar structure. Importantly, these simple lipid models are useful for investigating microstructure of the intercellular lipids in the stratum corneum.
File Format	HTM / HTML
ISSN	00092363
e-ISSN	13475223
Journal	Chemical and Pharmaceutical Bulletin
Issue Number	2
Volume Number	65
Language	English
Publisher	The Pharmaceutical Society of Japan
Publisher Date	2017-01-01
Publisher Place	Japan
Access Restriction	Open
Subject Keyword	Discipline Pharmacology Ceramides Chemistry Cholesterol Menthol Palmitic Acid Skin Metabolism Animals Mice Mice, Hairless Models, Biological Synchrotrons X-ray Diffraction
Content Type	Text
Resource Type	Article
Subject	Chemistry Medicine Drug Discovery

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