NDLI: The developing story of Sprouty and cancer.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Masoumi-Moghaddam, Samar Amini, Afshin Morris, David Lawson
Description	Author Affiliation: Masoumi-Moghaddam S ( UNSW Department of Surgery, University of New South Wales, St George Hospital, Kogarah, Sydney, NSW, 2217, Australia, samar.masoumi@gmail.com.)
Abstract	Sprouty proteins are evolutionarily conserved modulators of MAPK/ERK pathway. Through interacting with an increasing number of effectors, mediators, and regulators with ultimate influence on multiple targets within or beyond ERK, Sprouty orchestrates a complex, multilayered regulatory system and mediates a crosstalk among different signaling pathways for a coordinated cellular response. As such, Sprouty has been implicated in various developmental and physiological processes. Evidence shows that ERK is aberrantly activated in malignant conditions. Accordingly, Sprouty deregulation has been reported in different cancer types and shown to impact cancer development, progression, and metastasis. In this article, we have tried to provide an overview of the current knowledge about the Sprouty physiology and its regulatory functions in health, as well as an updated review of the Sprouty status in cancer. Putative implications of Sprouty in cancer biology, their clinical relevance, and their proposed applications are also revisited. As a developing story, however, role of Sprouty in cancer remains to be further elucidated.
File Format	HTM / HTML
ISSN	01677659
e-ISSN	15737233
DOI	10.1007/s10555-014-9497-1
Journal	Cancer and Metastasis Reviews
Issue Number	2-3
Volume Number	33
Language	English
Publisher	Springer
Publisher Date	2014-09-01
Publisher Place	Netherlands
Access Restriction	Open
Subject Keyword	Discipline Neoplasms Intracellular Signaling Peptides And Proteins Metabolism Map Kinase Signaling System Neoplasms Animals Gene Expression Regulation, Neoplastic Genetics
Content Type	Text
Resource Type	Article
Subject	Cancer Research Oncology

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