NDLI: Histone H2A.Z deregulation in prostate cancer. Cause or effect?

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Dryhurst, Deanna Ausió, Juan
Description	Author Affiliation: Dryhurst D ( Department of Biochemistry and Microbiology, University of Victoria, Petch building, 258a, Victoria, British Columbia, Canada, V8W 3P6.)
Abstract	Genetic and epigenetic changes are at the root of all cancers. The epigenetic component involves alterations of the post-synthetic modifications of DNA (methylation) and histones (histone posttranslational modifications, PTMs) as well as of those of their molecular 'writers,' 'readers,' and 'erasers.' Noncoding RNAs (ncRNA) can also play a role. Here, we focus on the involvement of histone alterations in cancer, in particular that of the histone variant H2A.Z in the etiology of prostate cancer. The structural mechanisms putatively responsible for the contribution of H2A.Z to oncogenic gene expression programs are first described, followed by what is currently known about the involvement of this histone variant in the regulation of androgen receptor regulated gene expression. The implications of this and their relevance to oncogene deregulation in different stages of prostate cancer, including the progression toward androgen independence, are discussed. This review underscores the increasing awareness of the epigenetic contribution of histone variants to oncogenic progression.
File Format	HTM / HTML
ISSN	01677659
e-ISSN	15737233
DOI	10.1007/s10555-013-9486-9
Journal	Cancer and Metastasis Reviews
Issue Number	2-3
Volume Number	33
Language	English
Publisher	Springer
Publisher Date	2014-09-01
Publisher Place	Netherlands
Access Restriction	Open
Subject Keyword	Discipline Neoplasms Gene Expression Regulation, Neoplastic Histones Metabolism Prostatic Neoplasms Genetics Animals Disease Progression Epigenesis, Genetic Pathology Receptors, Androgen Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Cancer Research Oncology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in