NDLI: Src signaling pathways in prostate cancer.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Varkaris, Andreas Katsiampoura, Anastasia D. Araujo, John C. Gallick, Gary E. Corn, Paul G.
Description	Country affiliation: United States Author Affiliation: Varkaris A ( Department of Genitourinary Medical Oncology, The University of Texas, M.D. Anderson Cancer Center, Unit 1374 1155 Pressler St, Houston, TX, 77030, USA.)
Abstract	Knowledge of the molecular events that contribute to prostate cancer progression has created opportunities to develop novel therapy strategies. It is now well established that c-Src, a non-receptor tyrosine kinase, regulates a complex signaling network that drives the development of castrate-resistance and bone metastases, events that signal the lethal phenotype of advanced disease. Preclinical studies have established a role for c-Src and Src Family Kinases (SFKs) in proliferation, angiogenesis, invasion and bone metabolism, thus implicating Src signaling in both epithelial and stromal mechanisms of disease progression. A number of small molecule inhibitors of SFK now exist, many of which have demonstrated efficacy in preclinical models and several that have been tested in patients with metastatic castrate-resistant prostate cancer. These agents have demonstrated provocative clinic activity, particularly in modulating the bone microenvironment in a therapeutically favorable manner. Here, we review the discovery and basic biology of c-Src and further discuss the role of SFK inhibitors in the treatment of advanced prostate cancer.
File Format	HTM / HTML
ISSN	01677659
e-ISSN	15737233
DOI	10.1007/s10555-013-9481-1
Journal	Cancer and Metastasis Reviews
Issue Number	2-3
Volume Number	33
Language	English
Publisher	Springer
Publisher Date	2014-09-01
Publisher Place	Netherlands
Access Restriction	Open
Subject Keyword	Discipline Neoplasms Prostatic Neoplasms Metabolism Signal Transduction Src-family Kinases Animals Antineoplastic Agents Pharmacology Therapeutic Use Bone Neoplasms Cell Transformation, Neoplastic Genetics Gene Expression Regulation, Neoplastic Neoplasm Metastasis Neovascularization, Pathologic Drug Therapy Pathology Protein Binding Protein Kinase Inhibitors Receptors, Androgen Drug Effects Chemistry
Content Type	Text
Resource Type	Article
Subject	Cancer Research Oncology

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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