NDLI: Preparation of budesonide nanosuspensions for pulmonary delivery: Characterization, in vitro release and in vivo lung distribution studies.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Zhang, Yuan Zhang, Jianhua
Description	Author Affiliation: Zhang Y ( a Department of Pediatrics of Shanghai Jiao Tong University Affiliated Sixth People's Hospital , Shanghai , P. R. China.); Zhang J ( a Department of Pediatrics of Shanghai Jiao Tong University Affiliated Sixth People's Hospital , Shanghai , P. R. China.)
Abstract	The main objective of the present article was to prepare stable and well-dispersible budesonide (BUD) nanosuspensions by microfluidizer method. The morphology, particle size, and zeta potential of formulation were investigated and in vitro release and in vivo lung distribution were evaluated. Characterizations showed that BUD nanosuspensions were spherical in shape with a smooth surface. The measured average particle size was 122.5 ± 6.3 nm, and Î¶ potential was - 13.6 ± 0.4 mV. In vitro release behavior of three batches BUD nanosuspensions had a good reproduction. The deposition distribution of BUD different formulations was measured using a modified multi-stage liquid collision method. The data showed that BUD nanosuspensions have the most outstanding deposition distribution with fine particle ratio 82.2%. Compared with normal particle and micronized particles, nanosuspensions were easier to be distributed in lung. After inhalation of 1 h, the drug concentration can reach 872.9 ng/g, which was extremely significantly different from normal particles (p < 0.01) and significantly different from micronized particles (p < 0.05).
File Format	HTM / HTML
ISSN	21691401
Issue Number	1
Volume Number	44
e-ISSN	2169141X
Journal	Artificial Cells, Nanomedicine, and Biotechnology
Language	English
Publisher	Taylor & Francis
Publisher Date	2016-01-01
Publisher Place	Great Britain (UK)
Access Restriction	Subscribed
Subject Keyword	Discipline Nanotechnology Discipline Biotechnology Bronchodilator Agents Pharmacokinetics Budesonide Drug Carriers Nanoparticles Chemistry Administration, Inhalation Animals Chemical Synthesis Drug Compounding Methods Drug Liberation Female Guinea Pigs Lung Drug Effects Metabolism Male Ultrastructure Particle Size Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Medicine Biomedical Engineering Biotechnology Pharmaceutical Science

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