NDLI: Surface-modified bacterial nanofibrillar PHB scaffolds for bladder tissue repair.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Karahaliloglu, Zeynep Demirbilek, Murat Sam, Mesut Saglam, Necdet Mizrak, Alpay Koray Denkbas, Emir Baki
Description	Country affiliation: Turkey Author Affiliation: Karahaliloglu Z ( a Division of Nanotechnology and Nanomedicine, Hacettepe University , Beytepe , Ankara , Turkey.); Demirbilek M ( a Division of Nanotechnology and Nanomedicine, Hacettepe University , Beytepe , Ankara , Turkey.); Sam M ( b Department of Biology , Aksaray University , Aksaray , Turkey.); Saglam N ( a Division of Nanotechnology and Nanomedicine, Hacettepe University , Beytepe , Ankara , Turkey.); Mizrak AK ( c UNAM, Institute of Materials Science and Nanotechnology, Bilkent University , Bilkent , Ankara , Turkey.); Denkbas EB ( a Division of Nanotechnology and Nanomedicine, Hacettepe University , Beytepe , Ankara , Turkey.)
Abstract	The aim of the study is in vitro investigation of the feasibility of surface-modified bacterial nanofibrous poly [(R)-3-hydroxybutyrate] (PHB) graft for bladder reconstruction. In this study, the surface of electrospun bacterial PHB was modified with PEG- or EDA via radio frequency glow discharge method. After plasma modification, contact angle of EDA-modified PHB scaffolds decreased from 110 ± 1.50 to 23 ± 0.5 degree. Interestingly, less calcium oxalate stone deposition was observed on modified PHB scaffolds compared to that of non-modified group. Results of this study show that surface-modified scaffolds not only inhibited calcium oxalate growth but also enhanced the uroepithelial cell viability and proliferation.
File Format	HTM / HTML
ISSN	21691401
Issue Number	1
Volume Number	44
e-ISSN	2169141X
Journal	Artificial Cells, Nanomedicine, and Biotechnology
Language	English
Publisher	Taylor & Francis
Publisher Date	2016-01-01
Publisher Place	Great Britain (UK)
Access Restriction	Subscribed
Subject Keyword	Discipline Nanotechnology Discipline Biotechnology Biocompatible Materials Pharmacology Epithelial Cells Drug Effects Hydroxybutyrates Regeneration Urinary Bladder Animals Isolation & Purification Metabolism Calcium Oxalate Chemistry Cell Line Cell Proliferation Cell Survival Cupriavidus Necator Pathology Ethylenediamines Kidney Calculi Mice Polyethylene Glycols Polymerization Tissue Engineering Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Medicine Biomedical Engineering Biotechnology Pharmaceutical Science

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