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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Akimaru, Michiko Okubo, Kohei Hiruta, Yuki Kanazawa, Hideko |
| Description | Author Affiliation: Akimaru M ( Faculty of Pharmacy, Keio University.) |
| Abstract | We have developed a novel solid-phase extraction (SPE) system utilizing a temperature-responsive polymer hydrogel-modified stationary phase. Aminopropyl silica beads (average diameter, 40 - 64 µm) were coated with poly(N-isopropylacrylamide) (PNIPAAm)-based thermo-responsive hydrogels. Butyl methacrylate (BMA) and N,N-dimethylaminopropyl acrylamide (DMAPAAm) were used as the hydrophobic and cationic monomers, respectively, and copolymerized with NIPAAm. To evaluate the use of this SPE cartridge for the analysis of drugs and proteins in biological fluids, we studied the separation of phenytoin and theophylline from human serum albumin (HSA) as a model system. The retention of the analytes in an exclusively aqueous eluent could be modulated by changing the temperature and salt content. These results indicated that this temperature-responsive SPE system can be applied to the pretreatment of biological samples for the measurement of serum drug levels. |
| File Format | HTM / HTML |
| ISSN | 09106340 |
| e-ISSN | 13482246 |
| Journal | Analytical Sciences |
| Issue Number | 9 |
| Volume Number | 31 |
| Language | English |
| Publisher | The Japan Society for Analytical Chemistry |
| Publisher Date | 2015-01-01 |
| Publisher Place | Japan |
| Access Restriction | Open |
| Subject Keyword | Discipline Analytical Discipline Chemistry Techniques Analytic Sample Preparation Methods Solid Phase Extraction Temperature Acrylic Resins Chemistry Hydrogels Hydrophobic And Hydrophilic Interactions Phenytoin Isolation & Purification Serum Albumin Silicon Dioxide Surface Properties Theophylline Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Analytical Chemistry |
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