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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Wu, Zhen Wirth, Mary J. Zhang, Zhaorui |
| Description | Country affiliation: United States Author Affiliation: Zhang Z ( Purdue University, Department of Chemistry, 560 Oval Drive, West Lafayette, IN 47907, USA.) |
| Abstract | A chromatographic column of nonporous silica particles with a bonded phase of linear polyacrylamide chains is evaluated for hydrophilic interaction liquid chromatography (HILIC) of intact glycoproteins. The column is shown to retain glycoproteins significantly more strongly than non-glycoproteins. A particle diameter of 700nm gives two-fold higher resolution than does a 1.4µm particle diameter, and the column efficiency is found to be mostly limited by packing heterogeneity. LCMS is able to resolve the five glycoforms of ribonuclease B and give high quality mass spectra, but there is loss of resolution of the isomers of glycoforms due to the lower amount of TFA. Compared to two leading commercial HILIC columns operated at 60°C, the polyacrylamide column operated at 30°C provided at least two-fold higher resolution for intact ribonuclease B, and showed peaks for glycoforms of prostate specific antigen, although not resolved. |
| ISSN | 00219673 |
| e-ISSN | 18733778 |
| DOI | 10.1016/j.chroma.2013.05.076 |
| Journal | Journal of Chromatography A |
| Volume Number | 1301 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2013-08-02 |
| Publisher Place | Netherlands |
| Access Restriction | Open |
| Subject Keyword | Acrylic Resins Chemistry Chromatography, Liquid Instrumentation Glycoproteins Hydrophobic And Hydrophilic Interactions Silicon Dioxide Research Support, N.i.h., Extramural Discipline Analytical Chemistry |
| Content Type | Text |
| Resource Type | Article |
| Subject | Organic Chemistry Medicine Analytical Chemistry Biochemistry |
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