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High body mass alters colonic sensory-motor function and transit in humans.

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High body mass alters colonic sensory-motor function and transit in humans.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Delgado-Aros, Silvia Camilleri, Michael Garcia, Montse Andreu Burton, Duane Busciglio, Irene
Description	Country affiliation: Spain Author Affiliation: Delgado-Aros S ( Enteric Neuroscience Immune Inflammatory and Obesity Research (ENIOR) Group, Municipal Institute for Medical Research (IMIM-Hospital del Mar), Barcelona Biomedical Research Park (PRBB), Barcelona, Spain.)
Abstract	There is increased prevalence of abdominal pain and diarrhea and decreased gastric sensation with increased body mass index (BMI). Our hypothesis is that increased BMI is associated with increased colonic motility and sensation. The study aim was to assess effect of BMI on colonic sensory and motor functions and transit. We used a database of colonic tone, compliance, and perception of distensions measured by intracolonic, barostat-controlled balloon, and gastrointestinal transit was measured by validated scintigraphy in healthy obese and nonobese subjects. Regression analysis was applied to assess the association of BMI with colonic sensory and motor functions. We included adjustments for sex differences, age, height, balloon volumes during distension, and psychological stress. Among 165 participants (87 women, 78 men), increased BMI was associated with decreased colonic compliance (P < 0.006, adjusted), decreased pain rating during distensions (P = 0.02, adjusted), and a higher threshold for pain (P = 0.042, adjusted). Sensation for gas, colonic tone, and contraction after meal ingestion were not significantly associated with BMI. Transit was assessed in 72 participants (41 women, 31 men); colonic transit was faster with BMI >30 kg/m(2) (P = 0.003 unadjusted, P = 0.08 adjusted for gender). In conclusion, BMI >25 kg/m(2) is associated with decreased colonic compliance and pain sensation; colonic transit is accelerated particularly with BMI >30 kg/m(2) in women. These data suggest that colonic dysfunction may contribute to diarrhea, but the cause of increased abdominal pain in obesity is not explained by the studies of colonic sensation and requires further study of afferent, spinal, and central mechanisms.
File Format	HTM / HTML
ISSN	01931857
e-ISSN	15221547
DOI	10.1152/ajpgi.90286.2008
Journal	AJP: Gastrointestinal and Liver Physiology
Issue Number	2
Volume Number	295
Language	English
Publisher	American Physiological Society
Publisher Date	2008-08-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Physiology Discipline Gastroenterology Colon Physiology Gastrointestinal Transit Obesity Physiopathology Sensory Thresholds Body Mass Index Compliance Pain Etiology Pressure Research Support, N.i.h., Extramural
Content Type	Text
Resource Type	Article
Subject	Hepatology Physiology Physiology (medical) Gastroenterology

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