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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Lin, Wan-Yi Hu, Yu-Jie Lee, Ying-Hue |
| Description | Country affiliation: Taiwan Author Affiliation: Lin WY ( Laboratory of Molecular Pathology, Institute of Molecular Biology, Academia Sinica, Taipei 115, Taiwan.) |
| Abstract | Hepatocyte nuclear factor 1alpha (HNF-1alpha) is a homeodomain-containing transcription factor and is important in postnatal growth and development in mice. In the HNF-1alpha-deficient liver, the expressions of a large set of growth hormone (GH)-responsive genes were significantly downregulated. By analyzing various HNF-1alpha mutant mice, we disclosed a mechanism by which hepatic HNF-1alpha regulates the expression of GH-responsive genes that are crucial for growth and development. We found that HNF-1alpha is required for the normal expression of glucocorticoid receptor (GR) specifically in livers. In the liver, GR, together with STAT5, is known to mediate the GH action by transactivating the GH-responsive genes that function in body growth and development. We further demonstrated that HNF-1alpha modulated GR gene expression by directly transactivating the GR gene promoter via a cryptic regulatory element located 3 bp upstream of the translation start site in exon 2 of the GR gene locus. |
| File Format | HTM / HTML |
| ISSN | 01931857 |
| e-ISSN | 15221547 |
| DOI | 10.1152/ajpgi.00081.2008 |
| Journal | AJP: Gastrointestinal and Liver Physiology |
| Issue Number | 3 |
| Volume Number | 295 |
| Language | English |
| Publisher | American Physiological Society |
| Publisher Date | 2008-09-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Discipline Physiology Discipline Gastroenterology Body Size Genetics Gene Expression Regulation, Developmental Hepatocyte Nuclear Factor 1-alpha Metabolism Liver Receptors, Glucocorticoid Aging Animals Chromatin Immunoprecipitation Exons Genes, Reporter Growth And Development Mice Mice, Knockout Mice, Transgenic Promoter Regions, Genetic Regulatory Sequences, Nucleic Acid Stat5 Transcription Factor Transcription Initiation Site Transcription, Genetic Transcriptional Activation Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Hepatology Physiology Physiology (medical) Gastroenterology |
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