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Effects of cholecystokinin-58 on type 1 cholecystokinin receptor function and regulation

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Effects of cholecystokinin-58 on type 1 cholecystokinin receptor function and regulation

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Wu, S. Vincent Harikumar, Kaleeckal G. Burgess, Rebecca J. Reeve, Joseph R. Miller, Laurence J.
Description	Country affiliation: United States Author Affiliation: Wu SV ( Mayo Clinic, Department of Molecular Pharmacology and Experimental Therapeutics, 13400 East Shea Blvd., Scottsdale, AZ 85259, USA.)
Abstract	Cholecystokinin, like many peptide hormones, is present as multiple molecular forms. CCK-58 has been identified as the dominant form in the circulation, whereas most of the studies of CCK-receptor interactions have been performed with CCK-8. Despite both sharing the pharmacophoric region of CCK, representing its carboxy terminal heptapeptide amide, studies in vivo have demonstrated biological diversity of action of the two peptides, with CCK-58, but not CCK-8, stimulating pancreatic fluid secretion and lengthening the interval between meals. Here, we have directly studied the ability of these two CCK peptides to bind to the type 1 CCK receptor and to stimulate it to elicit an intracellular calcium response. The calcium response relative to receptor occupation was identical for CCK-58 and CCK-8, with the longer peptide binding with approximately fivefold lower affinity. We also examined the ability of the two peptides to elicit receptor internalization using morphological techniques and to disrupt the constitutive oligomerization of the CCK receptor using receptor bioluminescence resonance energy transfer. Here, both full agonist peptides had similar effects on these regulatory processes. These data suggest that both molecular forms of CCK act at the $CCK_{1}$ receptor quite similarly and elicit similar regulatory processes for that receptor, suggesting that the differences in biological activity observed in vivo most likely reflect differences in the clearance and/or metabolism of these long and short forms of CCK peptides.
File Format	HTM / HTML
ISSN	01931857
e-ISSN	15221547
DOI	10.1152/ajpgi.90390.2008
Journal	AJP: Gastrointestinal and Liver Physiology
Issue Number	3
Volume Number	295
Language	English
Publisher	American Physiological Society
Publisher Date	2008-09-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Physiology Discipline Gastroenterology Calcium Signaling Cholecystokinin Metabolism Receptors, Cholecystokinin Animals Cho Cells Cos Cells Cercopithecus Aethiops Cricetinae Cricetulus Endocytosis Fluorescence Resonance Energy Transfer Luciferases, Renilla Luminescent Proteins Protein Binding Genetics Recombinant Fusion Proteins Sincalide Analogs & Derivatives Time Factors Transfection Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't Research Support, U.s. Gov't, Non-p.h.s.
Content Type	Text
Resource Type	Article
Subject	Hepatology Physiology Physiology (medical) Gastroenterology

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Effects of cholecystokinin-58 on type 1 cholecystokinin receptor function and regulation

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