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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Kyrmizi, Irene Hatzis, Pantelis Katrakili, Nitsa Tronche, Francois Gonzalez, Frank J. Talianidis, Iannis |
| Description | Country affiliation: Greece Author Affiliation: Kyrmizi I ( Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology, Hellas, 711 10 Herakleion, Crete, Greece.) |
| Abstract | Cross-regulatory cascades between hepatic transcription factors have been implicated in the determination of the hepatic phenotype. Analysis of recruitments to regulatory regions and the temporal and spatial expression pattern of the main hepatic regulators during liver development revealed a gradual increase in complexity of autoregulatory and cross-regulatory circuits. Within these circuits we identified a core group of six transcription factors, which regulate the expression of each other and the expression of other downstream hepatic regulators. Changes in the promoter occupancy patterns during development included new recruitments, release, and exchange of specific factors. We also identified promoter and developmental stage-specific dual regulatory functions of certain factors as an important feature of the network. Inactivation of HNF-4alpha in embryonic, but not in adult, liver resulted in the diminished expression of most hepatic factors, demonstrating that the stability of the network correlates with its complexity. The results illustrate the remarkable flexibility of a self-sustaining transcription factor network, built up by complex dominant and redundant regulatory motifs in developing hepatocytes. |
| File Format | HTM / HTML |
| ISSN | 08909369 |
| e-ISSN | 15495477 |
| Journal | Genes & Development |
| Issue Number | 16 |
| Volume Number | 20 |
| Language | English |
| Publisher | Cold Spring Harbor Laboratory Press |
| Publisher Date | 2006-08-15 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Discipline Molecular Discipline Biology__semicolon__developmental Discipline Biology__semicolon__genetics__semicolon__cell Discipline Biology Gene Expression Regulation, Developmental Hepatocytes Cytology Metabolism Liver Embryology Transcription Factors Animals Cell Differentiation Chromatin Immunoprecipitation Exons Hepatocyte Nuclear Factor 4 Genetics Growth & Development Mice Promoter Regions, Genetic Rna, Messenger Reverse Transcriptase Polymerase Chain Reaction Specific Pathogen-free Organisms Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Genetics Developmental Biology |
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