NDLI: Creatine transporter expression after antidepressant therapy in rats bred for learned helplessness.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Lugenbiel, Patrick Sartorius, Alexander Vollmayr, Barbara Schloss, Patrick
Description	Country affiliation: Germany Author Affiliation: Lugenbiel P ( Central Institute of Mental Health, Mannheim, Germany.)
Abstract	In cells and tissues with a high demand of energy such as neurons the major pool of energy is supplied by phosphocreatine. The necessary supply with creatine is directly related to the expression level of the creatine transporter (CRT). To study possible interactions between this transporter and depressive like behavior we have used a congenitally learned helplessness (cLH) model. Because uptake via CRT is the only means to supply neurons with creatine, we hypothesized a rise in CRT expression following antidepressive treatment strategies. The hippocampus of the cLH animals exhibited a significantly lower CRT expression as compared to wild type (WT) animals. Treatment with escitalopram and ECS induced an elevation of CRT levels in the hippocampus and the prefrontal cortex. In WT animals there was no treatment effect. In summary, our data presented here suggest an association between depressive behavior and cellular energy metabolism in defined brain areas.
File Format	HTM / HTML
ISSN	15622975
Part	Pt 2
Volume Number	11
e-ISSN	18141412
Journal	The World Journal of Biological Psychiatry
Issue Number	2
Language	English
Publisher	Taylor & Francis
Publisher Date	2010-03-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Psychiatry Antidepressive Agents, Second-generation Pharmacology Citalopram Helplessness, Learned Membrane Transport Proteins Biosynthesis Actins Analysis Animals Female Gene Expression Drug Effects Hippocampus Chemistry Male Prefrontal Cortex Rats Rats, Sprague-dawley Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Biological Psychiatry Psychiatry and Mental Health

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