NDLI: Elevated total cholesterol in severely depressed patients: role in cardiovascular risk?

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Das, Partha Pratim Malhotra, Savita Chakrabarti, Subho Sharma, Sadhna
Description	Country affiliation: India Author Affiliation: Das PP ( Department of Psychiatry, Postgraduate Institute of Medical Education & Research, Chandigarh, India. drparthapratimdas@yahoo.com)
Abstract	BACKGROUND: Cholesterol is an essential component of cell membrane constituting the neuronal cells and mediates multiple functions affecting neuronal transmission in the central nervous system. Abnormalities in serum lipid fractions have been reported in depression, but the clinical and biological significance of such findings are yet to be elucidated. AIMS AND OBJECTIVE: To study the abnormalities of lipid fractions in subjects with unipolar depression. METHODOLOGY: Thirty patients with unipolar depression and normal controls were recruited in this study. Serum total cholesterol, low-density lipoprotein, high-density lipoprotein, very low-density lipoprotein, and triglycerides were studied. Data analysis was performed by using an analysis of covariance (ANCOVA) controlling for age, sex, body mass index, lifestyle, and dietary habits. RESULTS: The data showed significant elevation of serum total cholesterol in depressed patients compared with normal controls. Identical results were obtained after controlling for the effects of confounders. CONCLUSION: Results of this study point to particular subgroup of subjects who have elevated cholesterol among the depressed cohort. This may have significant implications in risk assessment for cardiovascular disorders and planning preventive strategies.
File Format	HTM / HTML
ISSN	15622975
Part	Pt 2
Volume Number	11
e-ISSN	18141412
Journal	The World Journal of Biological Psychiatry
Issue Number	2
Language	English
Publisher	Taylor & Francis
Publisher Date	2010-03-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Psychiatry Cholesterol Blood Depressive Disorder Adult Age Factors Analysis Of Variance Cardiovascular Diseases Etiology Case-control Studies Complications Feeding Behavior Female Humans Lipoproteins, Hdl Lipoproteins, Ldl Male Middle Aged Psychiatric Status Rating Scales Regression Analysis Risk Factors Severity Of Illness Index Sex Factors Statistics, Nonparametric Triglycerides Young Adult Journal Article
Content Type	Text
Resource Type	Article
Subject	Biological Psychiatry Psychiatry and Mental Health

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