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Year: 2010 Volume: 11 Issue: 1

Year: 2010 Volume: 11 Issue: Supplementary 1

Year: 2009 Volume: 10

Year: 2008 Volume: 9

Effect of dopamine on intracellular sodium: a common pathway for pharmacological mechanism of action in bipolar illness.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Roberts, Rona J. Repass, Richard El-Mallakh, Rif S.
Description	Country affiliation: United States Author Affiliation: Roberts RJ ( Mood Disorders Research Program, Department of Psychiatry and Behavioral Sciences, University of Louisville School of Medicine, Louisville, KY 40202, USA.)
Abstract	BACKGROUND: The pathogenesis of bipolar illness is unknown. A search for common mechanism of action in effective medications has been utilized as a method to gain clues into mechanisms of illness. The recent increase of reports of documented efficacy of first- and second-generation antipsychotics in the control of mania offers a new opportunity to gain insight into the pathophysiological mechanism of bipolar disorder. METHODS: A selected critical review of the literature is performed to gain insights into the effect of antipsychotic medications on ion regulation. RESULTS: Dopamine D(1) and D(2) receptor stimulation increases intracellular sodium concentrations. D(1) and D(2) blockade normalizes stimulated intracellular sodium concentrations, and increases active sodium pump expression. CONCLUSIONS: A similar exercise has previously suggested that lithium and effective anticonvulsants reduce sodium influx in an activity-dependent manner. The current review suggests that antipsychotic medications may have a similar effect by a different mechanism. The role of ion dysregulation in the genesis of mania in bipolar illness needs to continue to be examined.
File Format	HTM / HTML
ISSN	15622975
Part	Pt 2
Volume Number	11
e-ISSN	18141412
Journal	The World Journal of Biological Psychiatry
Issue Number	2
Language	English
Publisher	Taylor & Francis
Publisher Date	2010-03-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Psychiatry Bipolar Disorder Drug Therapy Dopamine Physiology Sodium Animals Antipsychotic Agents Pharmacology Therapeutic Use Physiopathology Humans Lithium Compounds Receptors, Dopamine D1 Drug Effects Receptors, Dopamine D2 Metabolism Journal Article Research Support, Non-u.s. Gov't Review
Content Type	Text
Resource Type	Article
Subject	Biological Psychiatry Psychiatry and Mental Health

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