NDLI: In vitro and in vivo cardiomyogenic differentiation of amniotic fluid stem cells.

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Year: 2011 Volume: 7 Issue: 1

In vitro and in vivo cardiomyogenic differentiation of amniotic fluid stem cells.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Bollini, Sveva Pozzobon, Michela Nobles, Muriel Riegler, Johannes Dong, Xuebin Piccoli, Martina Chiavegato, Angela Price, Anthony N. Ghionzoli, Marco Cheung, King K. Cabrelle, Anna O'Mahoney, Paul R. Cozzi, Emanuele Sartore, Saverio Tinker, Andrew Lythgoe, Mark F. De Coppi, Paolo
Description	Country affiliation: Italy Author Affiliation: Bollini S ( Stem Cell Processing Laboratory-Fondazione Città della Speranza, Venetian Institute of Molecular Medicine (VIMM), University of Padua, Via G. Orus, 2, 35129, Padua, Italy. s.bollini@ich.ucl.ac.uk)
Abstract	Cell therapy has developed as a complementary treatment for myocardial regeneration. While both autologous and allogeneic uses have been advocated, the ideal candidate has not been identified yet. Amniotic fluid-derived stem (AFS) cells are potentially a promising resource for cell therapy and tissue engineering of myocardial injuries. However, no information is available regarding their use in an allogeneic context. c-kit-sorted, GFP-positive rat AFS (GFP-rAFS) cells and neonatal rat cardiomyocytes (rCMs) were characterized by cytocentrifugation and flow cytometry for the expression of mesenchymal, embryonic and cell lineage-specific antigens. The activation of the myocardial gene program in GFP-rAFS cells was induced by co-culture with rCMs. The stem cell differentiation was evaluated using immunofluorescence, RT-PCR and single cell electrophysiology. The in vivo potential of Endorem-labeled GFP-rAFS cells for myocardial repair was studied by transplantation in the heart of animals with ischemia/reperfusion injury (I/R), monitored by magnetic resonance imaging (MRI). Three weeks after injection a small number of GFP-rAFS cells acquired an endothelial or smooth muscle phenotype and to a lesser extent CMs. Despite the low GFP-rAFS cells count in the heart, there was still an improvement of ejection fraction as measured by MRI. rAFS cells have the in vitro propensity to acquire a cardiomyogenic phenotype and to preserve cardiac function, even if their potential may be limited by poor survival in an allogeneic setting.
File Format	HTM / HTML
ISSN	15508943
Issue Number	2
Volume Number	7
e-ISSN	15586804
Journal	Stem Cell Reviews and Reports
Language	English
Publisher	Springer
Publisher Date	2011-06-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Cell Biology Amniotic Fluid Cytology Cell Differentiation Myocytes, Cardiac Stem Cells Animals Antigens, Differentiation Metabolism Cell Separation Methods Cell Transdifferentiation Coculture Techniques Disease Models, Animal Female Flow Cytometry Graft Rejection Green Fluorescent Proteins Myocardial Reperfusion Injury Therapy Myocardium Pathology Physiology Myosin Heavy Chains Pregnancy Rats Rats, Sprague-dawley Recombinant Fusion Proteins Single-cell Analysis Stem Cell Transplantation Transplantation, Homologous Troponin I Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Medicine

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