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Year: 2011 Volume: 7 Issue: 1

The potential of adipose stem cells in regenerative medicine.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Lindroos, Bettina Suuronen, Riitta Miettinen, Susanna
Description	Country affiliation: Finland Author Affiliation: Lindroos B ( Regea-Institute for Regenerative Medicine, University of Tampere and Tampere University Hospital, Tampere, Finland. bettina.lindroos@regea.fi)
Abstract	Adipose stem cells (ASCs) are an attractive and abundant stem cell source with therapeutic applicability in diverse fields for the repair and regeneration of acute and chronically damaged tissues. Importantly, unlike the human bone marrow stromal/stem stem cells (BMSCs) that are present at low frequency in the bone marrow, ASCs can be retrieved in high number from either liposuction aspirates or subcutaneous adipose tissue fragments and can easily be expanded in vitro. ASCs display properties similar to that observed in BMSCs and, upon induction, undergo at least osteogenic, chondrogenic, adipogenic and neurogenic, differentiation in vitro. Furthermore, ASCs have been shown to be immunoprivileged, prevent severe graft-versus-host disease in vitro and in vivo and to be genetically stable in long-term culture. They have also proven applicability in other functions, such as providing hematopoietic support and gene transfer. Due to these characteristics, ASCs have rapidly advanced into clinical trials for treatment of a broad range of conditions. As cell therapies are becoming more frequent, clinical laboratories following good manufacturing practices are needed. At the same time as laboratory processes become more extensive, the need for control in the processing laboratory grows consequently involving a greater risk of complications and possibly adverse events for the recipient. Therefore, the safety, reproducibility and quality of the stem cells must thoroughly be examined prior to extensive use in clinical applications. In this review, some of the aspects of examination on ASCs in vitro and the utilization of ASCs in clinical studies are discussed.
File Format	HTM / HTML
ISSN	15508943
Issue Number	2
Volume Number	7
e-ISSN	15586804
Journal	Stem Cell Reviews and Reports
Language	English
Publisher	Springer
Publisher Date	2011-06-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Cell Biology Adipose Tissue Cytology Adult Stem Cells Transplantation Regenerative Medicine Methods Immunology Metabolism Animals Antigens, Differentiation Cell Culture Techniques Cell Differentiation Clinical Trials As Topic Humans Immune System Diseases Therapy Trends Journal Article Research Support, Non-u.s. Gov't Review
Content Type	Text
Resource Type	Article
Subject	Medicine

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