NDLI: Correlations between photoactivable porphyrins' fluorescence, erythema and the pain induced by PDT on normal skin using ALA-derivatives.

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Year: 2013 Volume: 10 Issue: 3

Year: 2013 Volume: 10 Issue: 2

Year: 2013 Volume: 10 Issue: 1

Correlations between photoactivable porphyrins' fluorescence, erythema and the pain induced by PDT on normal skin using ALA-derivatives.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Barge, Jérôme Glanzmann, Thomas Zellweger, Matthieu Salomon, Denis Van Den Bergh, Hubert Wagnières, Georges
Description	Author Affiliation: Barge J ( Photoderma SA, Ch. du Raffort 6, 1055 Froideville, Switzerland. Electronic address: barge@photoderma.com.)
Abstract	BACKGROUND: Photodynamic therapy (PDT) with precursors of photoactivable porphyrins is a well-established treatment modality for skin pathologies as well as hair removal. Pain is a major side effect thereof, and it affects the treatment compliance and acceptance. METHODS: Five male subjects underwent a PDT procedure on normal skin, either with a diode laser (635 nm) or a lamp (405 nm), 3 or 6h after application of various precursors of photoactivable porphyrins (ALA 1M; Metvix(®) 1M; ALA-DGME 1M; ALA-DGME 3.66 M). Light doses ranged from 30 to 150 J/cm(2) and irradiances were 100 or 180 mW/cm(2). Fluorescence measurements were performed just before PDT, pain was quantified during PDT, and erythema was determined 24h afterwards. RESULTS: Because precursor ALA-DGME was very selective for the pilosebaceous apparatus vs. the epidermis, we solely carried out the PDTs using this precursor. In the absence of light, no pain was reported. An increase in pain was observed when increasing the irradiance. A correlation was observed between the follicular fluorescence and the maximal pain score during PDT. A correlation was observed between follicular fluorescence and skin erythema, and between pain score and skin erythema. CONCLUSIONS: With our well-controlled PDT parameters and homogenous subjects' conditions, we showed that pain could be reduced by reducing irradiance during PDT procedures. With the various correlations observed, we conclude that both pain and PaP fluorescence are useful tools to predict the post-PDT tissue effects (side effects and outcome). We suggest that A∂ nerve fibres would be the best candidate as first generators of PDT-induced pain.
File Format	HTM / HTML
ISSN	15721000
Issue Number	4
Volume Number	10
e-ISSN	18731597
Journal	Photodiagnosis and Photodynamic Therapy
Language	English
Publisher	Elsevier
Publisher Date	2013-12-01
Publisher Place	Netherlands
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Diagnostic Imaging Discipline Therapeutics Aminolevulinic Acid Adverse Effects Erythema Etiology Physiopathology Pain Porphyrins Metabolism Skin Adult Analogs & Derivatives Dose-response Relationship, Radiation Fluorescence Humans Male Middle Aged Photochemotherapy Photosensitizing Agents Reference Values Drug Effects Radiation Effects Spectrometry, Fluorescence Statistics As Topic Clinical Trial Comparative Study Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Biophysics Dermatology Pharmacology (medical) Oncology

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Correlations between photoactivable porphyrins' fluorescence, erythema and the pain induced by PDT on normal skin using ALA-derivatives.

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