NDLI: Clearance mechanism of protoporphyrin IX from mouse skin after application of 5-aminolevulinic acid.

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Clearance mechanism of protoporphyrin IX from mouse skin after application of 5-aminolevulinic acid.

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Clearance mechanism of protoporphyrin IX from mouse skin after application of 5-aminolevulinic acid.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Juzeniene, Asta Iani, Vladimir Moan, Johan
Description	Author Affiliation: Juzeniene A ( Department of Radiation Biology, Institute for Cancer Research, Oslo University Hospital, Montebello, 0310 Oslo, Norway. Electronic address: asta.juzeniene@rr-reearch.no.)
Abstract	BACKGROUND: 5-Aminolevulinic acid (ALA) or its esters mediated photodynamic therapy (PDT) is the most widely practiced form of PDT in dermatology. One of its advantages is that undesirable photosensitization lasts only for 24-48 h. In order to optimize ALA-PDT it is necessary to understand the mechanisms of intracellular production and clearance of PpIX (efflux from cells into blood stream and/or its conversion into haem). The aim of this study is to investigate the factors controlling the clearance of intracellular PpIX from healthy skin of mice. METHODS: PpIX was induced in mouse skin by topical or systemic application of ALA or by topical application of the iron chelator ethylenediaminetetraacetic acid (EDTA). Fluorescence spectroscopy was used to study PpIX kinetics in alive and dead skin. RESULTS: Topical application of ALA or EDTA leads to porphyrin production in living skin, but not in excised skin. The clearance rates of PpIX from alive and dead skin were the same in the absence of an intracellular ALA pool. The clearance half-life of EDTA-induced PpIX was 4-7 times longer than that of PpIX after application of ALA. CONCLUSIONS: Skin temperature and intracellular iron availability strongly affect PpIX clearance, while ALA application mode (topical versus systemic) and skin viability (dead versus alive) have no influence on PpIX decay. These results demonstrate that the clearance kinetics of PpIX from skin are determined mostly by the conversion of PpIX into haem, while the cellular efflux of PpIX into blood plays a minor role.
File Format	HTM / HTML
ISSN	15721000
Issue Number	4
Volume Number	10
e-ISSN	18731597
Journal	Photodiagnosis and Photodynamic Therapy
Language	English
Publisher	Elsevier
Publisher Date	2013-12-01
Publisher Place	Netherlands
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Diagnostic Imaging Discipline Therapeutics Aminolevulinic Acid Administration & Dosage Protoporphyrins Pharmacokinetics Skin Drug Effects Metabolism Administration, Topical Animals Female In Vitro Techniques Metabolic Clearance Rate Mice Mice, Inbred Balb C Mice, Nude Photosensitizing Agents Tissue Distribution Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Biophysics Dermatology Pharmacology (medical) Oncology

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