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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Guessennd, N. Bremont, S. Gbonon, V. Kacou-Ndouba, A. Ekaza, E. Lambert, T. Dosso, M. Courvalin, P. |
| Spatial Coverage | Cote d'Ivoire |
| Description | Author Affiliation: Guessennd N ( Laboratoire de bactériologie-virologie, institut Pasteur, BP 1563, Abidjan 08, Côte d'Ivoire. guessennd@yahoo.fr) |
| Abstract | The aim of the study was to show the emergence of the qnr genes in extended spectrum beta-lactamases producing enterobacteria in Abidjan between 2005 and 2006. The whole of 151 strains of extended spectrum beta-lactamases producing enterobacteria were studied: 64 Escherichia coli, 66 Klebsiella pneumoniae, seven Klebsiella oxytoca and 14 Enterobacter spp. isolated from various biological products and from in- and out-patients. The techniques of disks diffusion, double-disk synergy, E-test were respectively used for the antimicrobial susceptibility test, the detection of extended spectrum beta-lactamases and the minimal inhibiting concentration. The bla genes(SHV, TEM, CTXM groups 1, 2, 8, 9), and AmpC were determined by PCR and characterized by sequencing. A global prevalence of 27,2 % (41/151) and rates of 9,9, 14,6, 2,7 % for the qnr genes A, B, A and S were observed. The distribution was 42,9 % for Enterobacter spp, 31,2 % for Escherichia coli, 20,5 % for Klebsiella; 30 strains expressed at least two bla genes; four strains were associated with AmpC. The strains were resistant to the cotrimoxazole (97,6 %), to the céfépime (73,2 %), to the céfoxitine (56,1 %), to the imipénème (0 %) and 43,9 % to all the aminosides. This high qnr gene prevalence associated with several types of bla genes in epidemic matter, the high level of resistance to antibiotics make fear a high risk of the transmission of multi-resistants bacteria and challenge the authorities for a resistance monitoring policy. |
| File Format | HTM / HTML |
| ISSN | 03698114 |
| Issue Number | 7-8 |
| Volume Number | 56 |
| e-ISSN | 17683114 |
| Journal | Pathologie Biologie |
| Language | French |
| Publisher | Elsevier |
| Publisher Date | 2008-11-01 |
| Publisher Place | France |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Pathology Discipline Biology Bacterial Proteins Analysis Enterobacteriaceae Infections Microbiology Enterobacteriaceae Drug Effects Quinolones Pharmacology Beta-lactamases Body Fluids Community-acquired Infections Epidemiology Cote D'ivoire Cross Infection Dna, Bacterial Genetics Drug Resistance, Multiple, Bacterial Classification Enzymology Genes, Bacterial Humans Polymerase Chain Reaction Species Specificity Substrate Specificity Beta-lactam Resistance English Abstract Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pathology and Forensic Medicine |
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