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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Schramm, F. Moenne-Loccoz, R. Fafi-Kremer, S. Soulier, E. Royer, C. Weitten, T. Brignon, N. Ellero, B. Woehl-Jaegle, M-L Meyer, C. Wolf, P. Doffoel, M. Baumert, T-F Gut, J-P Stoll-Keller, F. Schvoerer, E. |
| Description | Country affiliation: France Author Affiliation: Schramm F ( Unité Inserm 748, 3, rue Koeberlé, 67000 Strasbourg, France. schrammfrederic@yahoo.fr) |
| Abstract | Besides hepatocytes, representing the main replication site of hepatitis C virus, peripheral blood mononuclear cells also represent a crucial target for viral infection. Hepatitis C virus compartmentalization (i.e., non-random distribution) of viral variants between plasma and peripheral blood mononuclear cells, more frequently observed in liver transplant patients compared to non-transplanted patients, makes liver transplantation an interesting model for the analysis of hepatitis C leukotropism. This article aims to present, firstly, in clinical and biological features arguing favour of hepatitis C virus infection leukotropism and, secondly, to review current knowledge about compartmentalization between plasma and peripheral blood mononuclear cells, especially in the liver transplantation setting. |
| File Format | HTM / HTML |
| ISSN | 03698114 |
| Issue Number | 7-8 |
| Volume Number | 56 |
| e-ISSN | 17683114 |
| Journal | Pathologie Biologie |
| Language | French |
| Publisher | Elsevier |
| Publisher Date | 2008-11-01 |
| Publisher Place | France |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Pathology Discipline Biology Hepacivirus Growth & Development Leukocytes, Mononuclear Virology Liver Transplantation Blood Cells Cohort Studies Cryoglobulinemia Genetics Isolation & Purification Physiology Hepatitis C, Chronic Complications Surgery Hepatocytes Humans Liver Liver Cirrhosis Etiology Lymphoma, Non-hodgkin Organ Specificity Polymorphism, Single-stranded Conformational Viral Envelope Proteins Virus Replication English Abstract Journal Article Review |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pathology and Forensic Medicine |
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