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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Wolf, Nicola M. Harris, Todd R. Kamita, Shizuo G. Tanaka, Hiromasa Wu, Zhaoju Hammock, Bruce D. Morisseau, Christophe |
| Description | Author Affiliation: Tanaka H ( Department of Entomology and the Cancer Research Center, University of California, Davis, CA 95616, USA.) |
| Abstract | Soluble epoxide hydrolase (sEH) is a multifunctional protein encoded by the EPHX2 gene. The biological functions and enzyme kinetics of sEH have been extensively investigated, however, little is known about its transcriptional regulation and mechanisms of tissue specific expression. Here, a luciferase gene based reporter assay was used to identify the minimal promoter and cis regulatory elements of EPHX2. The minimal promoter was identified as a GC-rich region between nts -374 and +28 with respect to the putative transcriptional start site. A reporter plasmid carrying this minimal promoter showed higher or similar activities in comparison to a reporter plasmid carrying nts -5,974 to +28 of EPHX2 in 9 human cell lines that were tested. Sp1 binding sites that are involved in augmenting the minimal promoter activity of EPHX2 were identified by nested deletion analysis, site-specific mutation, electrophoretic mobility shift assay, and chromatin immunoprecipitation assay. |
| ISSN | 00063002 |
| Journal | Biochimica et Biophysica Acta (BBA) - Reviews on Cancer |
| Issue Number | 1 |
| Volume Number | 1779 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2008-01-01 |
| Publisher Place | Netherlands |
| Access Restriction | Open |
| Subject Keyword | Epoxide Hydrolases Genetics 5' Flanking Region Cell Line Chromatin Immunoprecipitation Cytogenetics DNA Primers Electrophoretic Mobility Shift Assay GC Rich Sequence Gene Expression Regulation, Enzymologic Genes, Reporter Molecular Sequence Data Plasmids Promoter Regions, Genetic Reverse Transcriptase Polymerase Chain Reaction Transcription Initiation Site Transcription, Genetic Research Support, N.I.H., Extramural Biochemistry |
| Content Type | Text |
| Resource Type | Article |
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