NDLI: Polymorphisms in the p53 pathway genes and micronucleus occurrence in Chinese vinyl chloride-exposed workers.

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Polymorphisms in the p53 pathway genes and micronucleus occurrence in Chinese vinyl chloride-exposed workers.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Li, Yong Feng, Nan-Nan Zhang, Guang-Hui Wang, Qi Hao, Yan-Hui Long, Changxu Li, Yongliang Brandt-Rauf, Paul W. Xia, Zhao-Lin
Spatial Coverage	China
Description	Country affiliation: China Author Affiliation: Li Y ( Department of Occupational Health and Toxicology, School of Public Health, Fudan University, Shanghai, China.)
Abstract	OBJECTIVES: To investigate the association between polymorphisms in the p53 pathway genes and chromosomal damage in vinyl chloride (VC)-exposed workers. MATERIALS AND METHODS: Cytokinesis block micronucleus test was performed in 310 VC-exposed workers and 149 non-exposed workers to determine chromosomal damage. The polymerase chain reaction and restriction fragment length polymorphism technique were used to detect six SNPs in the p53 pathway genes involved in the cell cycle. RESULTS: There was a highly significant dose-response relationship between VC exposure and chromosomal damage. Individuals carrying the variant genotypes were at higher risk for chromosomal damage compared with their wild type genotype: p53rs1042522, MDM2 Del1518rs3730485, MDM2rs2279744 and GADD45Ars532446. On the other hand, individuals possessing the variant genotype of CDKN2A rs3088440 had significantly decreased risk compared with the corresponding wild-type. CONCLUSIONS: Genetic polymorphisms in P53 pathway genes may have an impact on VC-induced chromosomal damage.
File Format	HTM / HTML
ISSN	12321087
e-ISSN	1896494X
Journal	International Journal of Occupational Medicine and Environmental Health
Issue Number	6
Volume Number	26
Language	English
Publisher	Nofer Institute of Occupational Medicine
Publisher Date	2013-12-01
Publisher Place	Poland
Access Restriction	Open
Subject Keyword	Discipline Environmental Health Discipline Occupational Medicine Occupational Exposure Adverse Effects Polymorphism, Single Nucleotide Signal Transduction Genetics Tumor Suppressor Protein P53 Vinyl Chloride Toxicity Cell Cycle Cyclin-dependent Kinase Inhibitor P16 Dose-response Relationship, Drug Genotype Intracellular Signaling Peptides And Proteins Polymorphism, Restriction Fragment Length Drug Effects Proto-oncogene Proteins C-mdm2 Metabolism Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Public Health, Environmental and Occupational Health

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