NDLI: Polymorphisms in the p53 pathway genes and micronucleus occurrence in Chinese vinyl chloride-exposed workers

Please wait, while we are loading the content...

Polymorphisms in the p53 pathway genes and micronucleus occurrence in Chinese vinyl chloride-exposed workers

Content Provider	Semantic Scholar
Author	Li, Yong Feng, Nan-Nan Zhang, Guanghui Wang, Qi Hao, Yan-Hui Ya-Nanzhang Long, Changxu Li, Yong-Liang Brandt-Rauf, Paul W. Xia, Zhao‐lin
Copyright Year	2013
Abstract	ObjectivesTo investigate the association between polymorphisms in the p53 pathway genes and chromosomal damage in vinyl chloride (VC)-exposed workers.Materials and MethodsCytokinesis block micronucleus test was performed in 310 VC-exposed workers and 149 non-exposed workers to determine chromosomal damage. The polymerase chain reaction and restriction fragment length polymorphism technique were used to detect six SNPs in the p53 pathway genes involved in the cell cycle.ResultsThere was a highly significant dose-response relationship between VC exposure and chromosomal damage. Individuals carrying the variant genotypes were at higher risk for chromosomal damage compared with their wild type genotype: p53rs1042522, MDM2 Del1518rs3730485, MDM2rs2279744 and GADD45Ars532446. On the other hand, individuals possessing the variant genotype of CDKN2A rs3088440 had significantly decreased risk compared with the corresponding wild-type.ConclusionsGenetic polymorphisms in P53 pathway genes may have an impact on VC-induced chromosomal damage.
Starting Page	825
Ending Page	836
Page Count	12
File Format	PDF HTM / HTML
DOI	10.2478/s13382-013-0155-6
PubMed reference number	24464562
Journal	Medline
Volume Number	26
Alternate Webpage(s)	http://archive.sciendo.com/IJOMEH/ijomeh.2013.26.issue-6/s13382-013-0155-6/s13382-013-0155-6.pdf
Alternate Webpage(s)	http://ijomeh.eu/pdf-2132-2256?filename=Polymorphisms+in+the+p53.pdf
Alternate Webpage(s)	https://doi.org/10.2478/s13382-013-0155-6
Journal	International journal of occupational medicine and environmental health
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in