NDLI: Correlation of chromosome damage and promoter methylation status of the DNA repair genes MGMT and hMLH1 in Chinese vinyl chloride monomer (VCM)-exposed workers.

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Correlation of chromosome damage and promoter methylation status of the DNA repair genes MGMT and hMLH1 in Chinese vinyl chloride monomer (VCM)-exposed workers.

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Correlation of chromosome damage and promoter methylation status of the DNA repair genes MGMT and hMLH1 in Chinese vinyl chloride monomer (VCM)-exposed workers.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Wu, Fen Liu, Jing Qiu, Yu-Lan Wang, Wei Zhu, Shou-Min Sun, Pin Miao, Wen-Bin Li, Yong-Liang Brandt-Rauf, Paul W. Xia, Zhao-Lin
Spatial Coverage	China
Description	Country affiliation: China Author Affiliation: Wu F ( Department of Occupational Health and Toxicology, School of Public Health, Fudan University and Key Laboratory of Public Health and Safety of the Ministry of Education of China, Shanghai, China.)
Abstract	OBJECTIVE: To explore the association of the methylation status of MGMT and hMLH1 with chromosome damage induced by vinyl chloride monomer (VCM). MATERIALS AND METHODS: Methylation of MGMT and hMLH1 was measured in 101 VCM-exposed workers by methylation-specific PCR. Chromosome damage in peripheral blood lymphocytes was measured by the cytokinesis-block micronucleus assay. The subjects were divided into chromosome damaged and non-damaged groups based on the normal reference value of micronuclei frequencies determined for two control groups. RESULTS: MGMT promoter methylation was detectable in 5 out of 49 chromosome damaged subjects, but not in the chromosome non-damaged subjects; there was a significant difference in MGMT methylation between the two groups (p < 0.05). CONCLUSIONS: We detected aberrant promoter methylation of MGMT in a small number of chromosome damaged VCM-exposed workers, but not in the chromosome non-damaged subjects. This preliminary observation warrants further investigation in a larger study.
File Format	HTM / HTML
ISSN	12321087
e-ISSN	1896494X
Journal	International Journal of Occupational Medicine and Environmental Health
Issue Number	1
Volume Number	26
Language	English
Publisher	Nofer Institute of Occupational Medicine
Publisher Date	2013-03-01
Publisher Place	Poland
Access Restriction	Open
Subject Keyword	Discipline Environmental Health Discipline Occupational Medicine Adaptor Proteins, Signal Transducing Genetics Chromosomes, Human Drug Effects Dna Modification Methylases Dna Repair Enzymes Nuclear Proteins Occupational Exposure Adverse Effects Polymorphism, Genetic Tumor Suppressor Proteins Vinyl Chloride Metabolism Epidemiology Dna Damage Dna Repair Methylation Micronucleus Tests Occupational Diseases Polymerase Chain Reaction Comparative Study Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Public Health, Environmental and Occupational Health

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