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Year: 2008 Volume: 35 Issue: 2

Year: 2008 Volume: 35 Issue: 1

Year: 2008 Volume: 35 Issue: 4-5

Year: 2006 Volume: 33

Genetic affinity of two south Indian ethnic groups with other populations.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Jasti, S. Rakh, S. Pantula, V. Murthy, K. J. R. Valluri, V. L.
Spatial Coverage	India
Description	Country affiliation: India Author Affiliation: Jasti S ( Bhagawan Mahavir Medical Research Center, Hyderabad, India.)
Abstract	Humans appear to have spread to several parts of the Indian subcontinent by the middle Paleolithic period. It also provided a major passage for the distribution of modern humans. For the first time generic human leucocyte antigen (HLA) class II (DRB1) genotyping was performed using polymerase chain reaction-sequence-specific primer (PCR-SSP) (low-resolution) technique in two endogamous groups (Hindu-Brahmins and Sunni-Muslims) from the southern state of Andhra Pradesh in order to decipher the genetic affinity between them and with other populations. Calculation of genetic distances, construction of neighbour-joining dendograms and principal-component (P-C) maps were executed using HLA allelic frequencies. The present study reveals the genetic affinity of the Brahmin and Muslim populations from the state of Andhra Pradesh. The dendograms demonstrated that Indian populations form a separate cluster with oriental populations on one side and the eastern and the western Mediterranean populations on the other side. The principal component maps showed the clustering of Indian populations in the lower-right quadrant, where in the Sunni-Muslims occupied a position more closely to the north Indian Brahmins and the Bhargavas than to the geographically related south Hindu-Brahmin group. The study hypothesizes that unlike Brahmins who can be considered as an immediate stock of the Caucasians, the ancestors of Muslims might have been the result of an admixture between the Indo-Europeans and proto-Dravidians.
File Format	HTM / HTML
ISSN	17443121
Issue Number	3
Volume Number	35
e-ISSN	1744313X
Journal	International Journal of Immunogenetics
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2008-06-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Genetics Discipline Immunology Ethnic Groups Genetics Hla-dr Antigens Alleles Gene Frequency Genetic Variation Genetics, Population Hla-drb1 Chains Humans India Phylogeny Polymorphism, Genetic Principal Component Analysis Journal Article
Content Type	Text
Resource Type	Article
Subject	Genetics Molecular Biology Immunology Genetics (clinical)

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