NDLI: Evaluation of IL10, IL19 and IL20 gene polymorphisms and chronic hepatitis B infection outcome.

Please wait, while we are loading the content...

Molecular characterization of toll-like receptor 2 of ruminants and comparative expression in nilgai (Boselaphus tragocamelus) vs. buffalo (Bubalus bubalis).

Characterization, expression and evolution analysis of Toll-like receptor 1 gene in pufferfish (Tetraodon nigroviridis).

Association of vitamin D receptor polymorphisms with the outcome of allogeneic haematopoietic stem cell transplantation.

Interleukin-10 and interferon-gamma gene polymorphisms in patients with nasopharyngeal carcinoma.

Human MHC architecture and evolution: implications for disease association studies.

Regulatory region polymorphisms of vitamin D receptor gene in pulmonary tuberculosis patients and normal healthy subjects of south India.

Interleukin-10 promoter polymorphisms in patients with systemic lupus erythematosus from the Canary Islands.

Genetic affinity of two south Indian ethnic groups with other populations.

Evaluation of IL10, IL19 and IL20 gene polymorphisms and chronic hepatitis B infection outcome.

Year: 2008 Volume: 35 Issue: 2

Year: 2008 Volume: 35 Issue: 1

Year: 2008 Volume: 35 Issue: 4-5

Year: 2006 Volume: 33

Evaluation of IL10, IL19 and IL20 gene polymorphisms and chronic hepatitis B infection outcome.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Truelove, Ann L. Oleksyk, Taras K. Shrestha, Sadeep Thio, Chloe L. Goedert, James J. Donfield, Sharyne M. Kirk, Gregory D. Thomas, David L. O'Brien, Stephen J. Smith, Michael W.
Description	Country affiliation: United States Author Affiliation: Truelove AL ( Laboratory of Genomic Diversity, National Cancer Institute, Frederick, MD, USA.)
Abstract	Hepatitis B virus (HBV) infection remains a serious global health problem despite the availability of a highly effective vaccine. Approximately 5% of HBV-infected adults develop chronic hepatitis B, which may result in liver cirrhosis or hepatocellular carcinoma. Variants of interleukin-10 (IL10) have been previously associated with chronic hepatitis B infection and progression to hepatocellular carcinoma. Single nucleotide polymorphisms (SNP; n = 42) from the IL10, IL19 and IL20 gene regions were examined for an association with HBV infection outcome, either chronic or recovered, in a nested case-control study of African Americans and European Americans. Among African Americans, three nominally statistically significant SNP associations in IL10, two in IL20, and one haplotype association were observed with different HBV infection outcomes (P = 0.005-0.04). A SNP (rs1518108) in IL20 deviated significantly from Hardy-Weinberg equilibrium in African Americans, with a large excess of heterozygotes in chronic HBV-infected cases (P = 0.0006), which suggests a strong genetic effect. Among European Americans, a nominally statistically significant SNP association in IL20 and an IL20 haplotype were associated with HBV recovery (P = 0.01-0.04). These results suggest that IL10 and IL20 gene variants influence HBV infection outcome and encourage the pursuit of further studies of these cytokines in HBV pathogenesis.
File Format	HTM / HTML
ISSN	17443121
e-ISSN	1744313X
DOI	10.1111/j.1744-313X.2008.00770.x
Journal	International Journal of Immunogenetics
Issue Number	3
Volume Number	35
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2008-06-01
Publisher Place	Great Britain (UK)
Access Restriction	Open
Subject Keyword	Discipline Genetics Discipline Immunology Hepatitis B, Chronic Genetics Interleukin-10 Interleukins Polymorphism, Single Nucleotide African Americans Case-control Studies Disease Progression European Continental Ancestry Group Genotype Haplotypes Research Support, N.i.h., Extramural Research Support, N.i.h., Intramural Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Genetics Molecular Biology Immunology Genetics (clinical)

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Evaluation of IL10, IL19, and IL20 gene polymorphisms and chronic hepatitis B infection outcome

Association of interleukin-1 gene variations with moderate to severe chronic periodontitis in multiple ethnicities.

FcÎ³ receptor IIIa single-nucleotide polymorphisms and haplotypes affect human IgG binding and are associated with lupus nephritis in African Americans.

A genome-wide association study on African-ancestry populations for asthma.

Gene variation in IL10 and susceptibility to chronic hepatitis B.

CDX2 VDR polymorphism and colorectal cancer.

Viral hepatitis: human genes that limit infection.

A promoter polymorphism (rs3806798) of interleukin-15 gene is associated with chronic hepatitis B virus infection in the Chinese Han population.

APOL1 risk variants, race, and progression of chronic kidney disease.

Evaluation of IL10, IL19 and IL20 gene polymorphisms and chronic hepatitis B infection outcome.

Similar Documents

Evaluation of IL10, IL19, and IL20 gene polymorphisms and chronic hepatitis B infection outcome

Association of interleukin-1 gene variations with moderate to severe chronic periodontitis in multiple ethnicities.

FcÎ³ receptor IIIa single-nucleotide polymorphisms and haplotypes affect human IgG binding and are associated with lupus nephritis in African Americans.

A genome-wide association study on African-ancestry populations for asthma.

Gene variation in IL10 and susceptibility to chronic hepatitis B.

CDX2 VDR polymorphism and colorectal cancer.

Viral hepatitis: human genes that limit infection.

A promoter polymorphism (rs3806798) of interleukin-15 gene is associated with chronic hepatitis B virus infection in the Chinese Han population.

APOL1 risk variants, race, and progression of chronic kidney disease.

Evaluation of IL10, IL19 and IL20 gene polymorphisms and chronic hepatitis B infection outcome.