NDLI: Absence of chemopreventive influence of propolis on the rat liver altered foci development.

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Absence of chemopreventive influence of propolis on the rat liver altered foci development.

Adverse effects of arsenic exposure on uterine function and structure in female rat.

Year: 2010 Volume: 62 Issue: 3

Year: 2010 Volume: 62 Issue: 2

Year: 2010 Volume: 62 Issue: 1

Year: 2009 Volume: 61

Absence of chemopreventive influence of propolis on the rat liver altered foci development.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Said, Roueda Abou Grassi, Tony Fernando Scolastici, Clarissa Alves de Lima, Rodrigo Otávio Darros, Bruno R. Barbisan, Luis Fernando de Camargo, João Lauro V.
Spatial Coverage	Brazil
Description	Country affiliation: Brazil Author Affiliation: Said RA ( Department of Environmental and Agrarian Sciences, Santa Cruz State University, Ilhéus, Bahia, Brazil.)
Abstract	Propolis (bee glue) is a complex mixture of natural substances that exhibits a broad spectrum of biological activities. As the possibility exists that it may exert a chemopreventive role against cancer development, the present study aimed to evaluate the chemopreventive influence of a Brazilian aqueous propolis extract (APE) in a rat two-stage (initiation-promotion) medium-term bioassay for chemical liver carcinogenesis. Male Wistar rats were sequentially initiated with diethylnitrosamine (DEN, 200mg/kgb.w.) and, 2 weeks later, exposed to a diet containing hexachlorobenzene (HCB, 100ppm) and to APE 0.1% through drinking water for 6 weeks. Appropriate control groups were also established. The animals were sacrificed at the weeks 8th and 30th when liver samples were processed to evaluate the development of altered hepatocyte foci (AHF) identified under hematoxylin and eosin (H&E) staining and by the immunohistochemical expression of the enzyme glutathione S-transferase placental form (GST-P). The results indicate that APE 0.1% did not protect against the development of any of the differentially identified putative preneoplastic foci in DEN-initiated animals, exposed or not to the promoting agent HCB. Also, APE 0.1% by itself did not significantly induce any AHF, what is in line with its already known absence of genotoxic potential. Our results indicate that an aqueous extract of Brazilian propolis did not exert chemoprevention on the hepatocarcinogenesis process chemically induced in the rat.
File Format	HTM / HTML
ISSN	09402993
Issue Number	4
Volume Number	62
e-ISSN	16181433
Journal	Experimental and Toxicologic Pathology
Language	English
Publisher	Elsevier
Publisher Date	2010-07-01
Publisher Place	Germany
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Toxicology Discipline Pathology Anticarcinogenic Agents Therapeutic Use Liver Neoplasms Prevention & Control Liver Drug Effects Precancerous Conditions Propolis Animals Administration & Dosage Body Weight Brazil Cocarcinogenesis Diethylnitrosamine Toxicity Glutathione Transferase Biosynthesis Hexachlorobenzene Immunohistochemistry Enzymology Pathology Chemically Induced Male Medicine, Traditional Organ Size Rats Rats, Wistar Treatment Failure Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Cell Biology Toxicology Pathology and Forensic Medicine

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