NDLI: Short-term increase of serum troponin I and serum heart-type fatty acid-binding protein (H-FABP) in dogs following administration of formoterol.

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Short-term increase of serum troponin I and serum heart-type fatty acid-binding protein (H-FABP) in dogs following administration of formoterol.

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Short-term increase of serum troponin I and serum heart-type fatty acid-binding protein (H-FABP) in dogs following administration of formoterol.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Strauss, Volker Wöhrmann, Thomas Frank, Ilona Hübel, Ulrich Luft, Jörg Bode, Gerd Germann, Paul-Georg
Description	Country affiliation: Germany Author Affiliation: Strauss V ( Institute of Preclinical Drug Safety, Nycomed GmbH, Hamburg, Germany.)
Abstract	In this paper, changes in serum levels of the cardiac biomarkers troponin I and the heart-type fatty acid-binding protein (H-FABP) following administration of a long-acting beta(2)-sympathicomimeticum (long-acting beta-agonist, LABA) to dogs were measured. We measured troponin I in dogs in a 4-week repeated-dose study with inhalative administration of formoterol (13microg/kgd) and a glucocorticoid/formoterol combination (143/16microg/kgd). The medians of troponin I increased within 3 days in both groups, far beyond the cut-off level (0.1microg/L), but returned to baseline levels on study day 9. The increase was more pronounced in the formoterol-only group (3.29microg/L) compared to the glucocorticoid/formoterol combination group (1.32microg/L). In a second study, we measured serum troponin I as well as serum H-FABP levels in several samples over 7 days in dogs, receiving a single inhalative dose of a glucocorticoid/formoterol combination (120/12mug/kgd). The median of the troponin I concentration increased above the cut-off level within 2h and that of H-FABP within 4h. The medians of both parameters were temporarily above the cut-off levels even on study day 7. Both studies were conducted according to national animal welfare guidelines. To our knowledge, this is the first report that shows a corresponding increase of troponin I and H-FABP in dogs treated with formoterol. Both parameters are more sensitive in detecting a drug-induced cardiac injury compared to total LDH, total CK as well as CK MB activity. However, it is recommended to take at least three blood samples per day to assess a temporary increase of troponin I.
File Format	HTM / HTML
ISSN	09402993
Issue Number	4
Volume Number	62
e-ISSN	16181433
Journal	Experimental and Toxicologic Pathology
Language	English
Publisher	Elsevier
Publisher Date	2010-07-01
Publisher Place	Germany
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Toxicology Discipline Pathology Adrenergic Beta-2 Receptor Agonists Adverse Effects Ethanolamines Fatty Acid-binding Proteins Blood Troponin I Administration, Inhalation Administration & Dosage Animals Biological Markers Circadian Rhythm Delayed-action Preparations Dogs Dose-response Relationship, Drug Drug Combinations Female Formoterol Fumarate Glucocorticoids Male Myocardial Ischemia Chemically Induced Time Factors Journal Article
Content Type	Text
Resource Type	Article
Subject	Cell Biology Toxicology Pathology and Forensic Medicine

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