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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Konan, Nzi André Lincopan, Nilton Díaz, Ingrit Elida Collantes de Fátima Jacysyn, Jacqueline Tiba, Mirtes Midori Tanae Amarante Mendes, João Gustavo Pessini Bacchi, Elfriede Marianne Spira, Beny |
| Description | Country affiliation: Brazil Author Affiliation: Konan NA ( Departamento de Microbiologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, Brazil.) |
| Abstract | The leaves of the Cashew plant (Anacardium occidentale L.) are used by the folk medicine in South America and West Africa. This plant is rich in flavonoids, which are polyphenolic compounds widespread in plants, and that have diverse physiological effects. In a sub-acute toxicity assay it was found that an ethanolic extract of Cashew leaves elicited lymphopenia in rats. The extract was also found to be cytotoxic and to induce apoptosis in Jurkat (acute lymphoblastic leukemia) cells. The crude ethanolic extract was fractionated and resolved by HPLC. One of the four fractions obtained led to the isolation of the biflavonoid agasthisflavone. [(3)H]-thymidine incorporation assays and flow cytometry analysis showed that the isolated compound displayed a high anti-proliferative effect in Jurkat cells with an IC(50) of 2.4 µg/ml (4.45 µM). The effect of agathisflavone on the acute promyelocytic leukemia cell line HL60, Burkitt lymphoma Raji cells and Hep-2 laryngeal carcinoma cells was also tested. The two latter ones were only mildly affected by agathisflavone. It is also shown that agathisflavone induces apoptosis in Jurkat cells and it this proposed that this is the likely mechanism of agathisflavone specific cytotoxicity. |
| File Format | HTM / HTML |
| ISSN | 09402993 |
| Issue Number | 5 |
| Volume Number | 64 |
| e-ISSN | 16181433 |
| Journal | Experimental and Toxicologic Pathology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2012-07-01 |
| Publisher Place | Germany |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Toxicology Discipline Pathology Anacardium Chemistry Biflavonoids Pharmacology Cell Proliferation Drug Effects Lymphocytes Phytotherapy Methods Plant Extracts Animals Apoptosis Cell Line, Tumor Chromatography, High Pressure Liquid Flavonoids Flow Cytometry Hl-60 Cells Humans Jurkat Cells Male Plant Leaves Rats Rats, Wistar Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Toxicology Pathology and Forensic Medicine |
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