NDLI: Therapy with methanolic extract of Pterocarpus marsupium Roxb and Ocimum sanctum Linn reverses dyslipidemia and oxidative stress in alloxan induced type I diabetic rat model.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Singh, Prem Kumar Baxi, Darshee Banerjee, Sudip Ramachandran, A. V.
Description	Country affiliation: India Author Affiliation: Singh PK ( Division of Metabolic Endocrinology, Department of Zoology, The MS University of Baroda, Vadodara 390002, Gujarat, India.)
Abstract	Methanolic extracts of Pterocarpus marsupium Roxb (P. marsupium) and Ocimum sanctum Linn (O. sanctum) were prepared separately and then administered to both non-diabetic and alloxan induced diabetic adult female Wistar rats as a mixture of both at a dosage of 500mg/kg body weight, and its effect was checked on serum and tissue lipids together with corticosterone, estrogen and progesterone profile. Further, tissue load of metabolites (cholesterol), enzymatic and non-enzymatic antioxidant status together with lipid peroxidation levels and serum markers of hepatic and renal damage were also assessed. Results of the present study strongly support the possibility of this herbal combination in humans to meet the objective of achieving a holistic amelioration and cure of diabetes as, the herbal extract mixture of P. marsupium and O. sanctum has succeeded in not only rectifying dyslipidemia but also in restoring the endogenous antioxidant levels to the pre diabetic status. Herbal preparations are ideal candidates of choice and in this context, the present combination of P. marsupium and O. sanctum provides compelling evidence for a holistic efficacy in amelioration of associated diabetic manifestations/dysregulations.
File Format	HTM / HTML
ISSN	09402993
Issue Number	5
Volume Number	64
e-ISSN	16181433
Journal	Experimental and Toxicologic Pathology
Language	English
Publisher	Elsevier
Publisher Date	2012-07-01
Publisher Place	Germany
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Toxicology Discipline Pathology Antioxidants Pharmacology Diabetes Mellitus, Experimental Drug Therapy Diabetes Mellitus, Type 1 Phytotherapy Methods Plant Extracts Animals Disease Models, Animal Female Ocimum Chemistry Oxidative Stress Drug Effects Plant Bark Plant Leaves Plant Preparations Pterocarpus Rats Rats, Wistar Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Cell Biology Toxicology Pathology and Forensic Medicine

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