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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Selvaraj, Palanisamy Pugalendi, Kodukkur Viswanathan |
| Description | Country affiliation: India Author Affiliation: Selvaraj P ( Department of Biochemistry and Biotechnology, Annamalai University, Annamalainagar 608002, Tamil Nadu, India.) |
| Abstract | The present study examines the preventive role of hesperidin (HDN) on plasma, cardiac and hepatic lipids in isoproterenol (ISO)-induced rats. Myocardial injury was induced by subcutaneous injection of isoproterenol hydrochloride (85 mg/kg BW) twice at an interval of 24 h, for two consecutive days. HDN was administered by post-orally at a dose of 200 mg/kg BW. The results showed increased levels of plasma cholesterol, low density lipoprotein-cholesterol (LDL-C), very low density lipoprotein-cholesterol (VLDL-C), triglycerides (TG), free fatty acids (FFA) and phospholipids (PL) and decreased level of high density lipoprotein-cholesterol (HDL-C) in ISO-induced rats. ISO rats also showed an increase in cholesterol, TG and FFA and decrease in PL levels in the heart and liver tissues. HDN treatment brought the above parameters towards normal level. This experiment shows that HDN possesses hypolipidemic effect in ISO-induced rats. |
| File Format | HTM / HTML |
| ISSN | 09402993 |
| Issue Number | 5 |
| Volume Number | 64 |
| e-ISSN | 16181433 |
| Journal | Experimental and Toxicologic Pathology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2012-07-01 |
| Publisher Place | Germany |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Toxicology Discipline Pathology Heart Drug Effects Hesperidin Pharmacology Lipids Analysis Liver Myocardial Ischemia Metabolism Animals Cardiotonic Agents Toxicity Disease Models, Animal Isoproterenol Lipid Metabolism Blood Male Chemically Induced Rats Rats, Wistar Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Toxicology Pathology and Forensic Medicine |
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