NDLI: Cell protection induced by Acacia salicina extracts: inhibition of genotoxic damage and determination of its antioxidant capacity.

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Cell protection induced by Acacia salicina extracts: inhibition of genotoxic damage and determination of its antioxidant capacity.

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Cell protection induced by Acacia salicina extracts: inhibition of genotoxic damage and determination of its antioxidant capacity.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Bouhlel, Ines Bhouri, Wissem Limem, Ilef Boubaker, Jihed Nefatti, Aicha Skandrani, Ines Ben Sghaier, Mohammed Kilani, Soumaya Ghedira, Kamel Chekir Ghedira, Leila
Description	Country affiliation: Tunisia Author Affiliation: Bouhlel I ( Unité de Pharmacognosie/Biologie Moléculaire (99/UR/07-03), Faculté de Pharmacie de Monastir, Monastir, Tunisia.)
Abstract	Antioxidant activity of Acacia salicina extracts was determined by the ability of each extract to inhibit lipid peroxidation, to protect against DNA strand scission induced by hydroxyl radicals, and to scavenge the free radical, 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS(+)). The IC(50) values of the inhibitory activity toward lipid peroxidation of total oligomer flavonoids (TOF), methanol, ethyl acetate, and aqueous extracts were respectively 28, 52, 472, and 480 microg/mL. All extracts have the ability to scavenge the ABTS(+) radical by a hydrogen-donating mechanism and to protect pKS plasmid DNA against hydroxyl radicals- induced DNA damage. An assay for the ability of A. salicina extracts to prevent mutations induced by various mutagens in Salmonella typhimurium TA102 and TA104 cells was conducted. TOF, methanol, ethyl acetate, and aqueous extracts from leaf parts of A. salicina showed no mutagenicity either with or without the metabolic enzymes preparation (S9). Protection against methylmethanesulfonate-induced mutagenicity was observed for TOF, methanol, and ethyl acetate extracts. Likewise, all extracts exhibited a high inhibition level of the Ames response induced by the indirect mutagen, 2-aminoanthracene. The antigenotoxic activity could be ascribed, at least in part, to their antioxidant properties, but we cannot exclude additionally mechanisms. Thus, A. salicina may serve as an ideal candidate for a cost- effective, readily exploitable natural phytochemical compound.
File Format	HTM / HTML
ISSN	01480545
Issue Number	2
Volume Number	32
e-ISSN	15256014
Journal	Drug and Chemical Toxicology
Language	English
Publisher	Taylor & Francis
Publisher Date	2009-01-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Toxicology Acacia Chemistry Antimutagenic Agents Pharmacology Antioxidants Lipid Peroxidation Drug Effects Plant Extracts Cell Line, Tumor Cytoprotection Dose-response Relationship, Drug Flavonoids Free Radical Scavengers Humans K562 Cells Phytotherapy Protective Agents Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Health, Toxicology and Mutagenesis Public Health, Environmental and Occupational Health Toxicology Pharmacology Chemical Health and Safety

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