NDLI: Assessment of isorhamnetin 3-O-neohesperidoside from Acacia salicina: protective effects toward oxidation damage and genotoxicity induced by aflatoxin B1 and nifuroxazide

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Assessment of isorhamnetin 3-O-neohesperidoside from Acacia salicina: protective effects toward oxidation damage and genotoxicity induced by aflatoxin B1 and nifuroxazide

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Assessment of isorhamnetin 3-O-neohesperidoside from Acacia salicina: protective effects toward oxidation damage and genotoxicity induced by aflatoxin B1 and nifuroxazide

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Bouhlel, Ines Limem, Ilef Skandrani, Ines Nefatti, Aicha Ghedira, Kamel Dijoux-Franca, Marie-Genevieve Leila, Chekir-Ghedira
Description	Country affiliation: Tunisia Author Affiliation: Bouhlel I ( Unité de Pharmacognosie/Biologie Moléculaire 99/UR/07-03. Faculté de Pharmacie de Monastir, Rue Avicenne 5000 Monastir, Tunisia.)
Abstract	Antioxidant activity of isorhamnetin 3-O-neohesperidoside, isolated from the leaves of Acacia salicina, was determined by the ability of this compound to inhibit xanthine oxidase activity and to scavenge the free radical 2,2′-azino-bis (3-ethylbenzthiazoline-6-sulfonic acid) $(ABTS^{.−})$ diammonium salt. Antigenotoxic activity was assessed using the SOS chromotest assay. This compound has the ability to scavenge the $ABTS^{.+}$ radical by a hydrogen donating mechanism. We also envisaged the study of the antioxidant effect of this compound by the enzymatic xanthine/xanthine oxidase (X/XOD) assay. Results indicated that isorhamnetin 3-O-neohesperidoside was a potent inhibitor of xanthine oxidase and superoxide anion scavengers. Moreover, this compound induced an inhibitory activity against nifuroxazide and aflatoxine B1 (AFB1) induced genotoxicity. Taken together, these observations provide evidence that isorhamnetin 3-O-neohesperidoside isolated from the leaves of A. salicina is able to protect cells against the consequences of oxidative stress. Copyright © 2010 John Wiley & Sons, Ltd.
File Format	HTM / HTML
ISSN	0260437X
Issue Number	6
Volume Number	30
e-ISSN	10991263
Journal	Journal of Applied Toxicology
Language	English
Publisher	Wiley
Publisher Date	2010-08-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Toxicology Acacia Chemistry Aflatoxin B1 Toxicity Antimutagenic Agents Pharmacology Antioxidants Hydroxybenzoates Nitrofurans Oxidative Stress Drug Effects Animals Isolation & Purification Dna Repair Enzymes Metabolism Dose-response Relationship, Drug Flavonols Free Radicals Microsomes, Liver Mutagenicity Tests Plant Extracts Plant Leaves Rats Xanthine Oxidase Antagonists & Inhibitors Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Toxicology

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