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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Sanders, Heather R. Albitar, Maher |
| Description | Country affiliation: United States Author Affiliation: Sanders HR ( Quest Diagnostics Nichols Institute, 33608 Ortega Highway, San Juan Capistrano, CA 92675, USA. heather.r.sanders@questdiagnostics.com) |
| Abstract | Lung cancer is the leading cause of cancer-related deaths, with non-small-cell lung cancer (NSCLC) accounting for approximately 85% of cases. A significant proportion of NSCLC cases are not diagnosed until a late stage, when aggressive treatments are required but often prolong survival only modestly. Recent advances in molecular characterization of NSCLC have enabled identification of numerous cell growth and proliferation pathways that are disrupted in these tumors. This knowledge has provided insight into the mechanisms of tumor development in various histologic subtypes of NSCLC and has pointed the way toward targeted treatment strategies. In this review, we highlight literature findings of somatic mutations in genes involved in cell growth and proliferation that are commonly found in the various subtypes of NSCLC, and we discuss how these findings may relate to treatment strategies. |
| File Format | HTM / HTML |
| ISSN | 01654608 |
| Issue Number | 1 |
| Volume Number | 203 |
| e-ISSN | 18734456 |
| Journal | Cancer Genetics and Cytogenetics |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2010-11-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Cytology Discipline Genetics Discipline Oncology Carcinoma, Non-small-cell Lung Genetics Lung Neoplasms Mutation Signal Transduction Drug Therapy Genes, Tumor Suppressor Humans Intracellular Signaling Peptides And Proteins Physiology Mitogen-activated Protein Kinase Kinases Phosphatidylinositol 3-kinases Protein-serine-threonine Kinases Protein-tyrosine Kinases Proto-oncogene Proteins C-akt Receptor Protein-tyrosine Kinases Receptor, Epidermal Growth Factor Antagonists & Inhibitors Tor Serine-threonine Kinases Ras Proteins Journal Article Review |
| Content Type | Text |
| Resource Type | Article |
| Subject | Genetics Molecular Biology Cancer Research |
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