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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Radimerski, Thomas Montagne, Jacques Hemmings-Mieszczak, Maja Thomas, George |
| Description | Country affiliation: Switzerland Author Affiliation: Radimerski T ( Friedrich Miescher Institute for Biomedical Research, CH-4058, Basel, Switzerland.) |
| Abstract | Tuberous sclerosis complex (TSC) is a genetic disorder caused by mutations in one of two tumor suppressor genes, TSC1 and TSC2. Here, we show that absence of Drosophila Tsc1/2 leads to constitutive dS6K activation and inhibition of dPKB, the latter effect being relieved by loss of dS6K. In contrast, the dPTEN tumor suppressor, a negative effector of PI3K, has little effect on dS6K, but negatively regulates dPKB. More importantly, we demonstrate that reducing dS6K signaling rescues early larval lethality associated with loss of dTsc1/2 function, arguing that the S6K pathway is a promising target for the treatment of TSC. |
| File Format | HTM / HTML |
| ISSN | 08909369 |
| e-ISSN | 15495477 |
| Journal | Genes & Development |
| Issue Number | 20 |
| Volume Number | 16 |
| Language | English |
| Publisher | Cold Spring Harbor Laboratory Press |
| Publisher Date | 2002-10-15 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Discipline Molecular Discipline Biology__semicolon__developmental Discipline Biology__semicolon__genetics__semicolon__cell Discipline Biology Down-regulation Physiology Drosophila Melanogaster Metabolism Phosphatidylinositol 3-kinases Ribosomal Protein S6 Kinases Animals Cell Division Genetics Enzyme Activation Eye Growth & Development Genes, Insect Genes, Lethal Genes, Tumor Suppressor Mutation Pten Phosphohydrolase Phosphatidylinositol Phosphates Phosphoric Monoester Hydrolases Antagonists & Inhibitors Protein-serine-threonine Kinases Protein-tyrosine Kinases Proto-oncogene Proteins Proto-oncogene Proteins C-akt Rna, Double-stranded Pharmacology Signal Transduction Tuberous Sclerosis Pathology Tumor Suppressor Proteins Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Genetics Developmental Biology |
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