NDLI: Isoflurane Promotes Non-Small Cell Lung Cancer Malignancy by Activating the Akt-Mammalian Target of Rapamycin (mTOR) Signaling Pathway.

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Isoflurane Promotes Non-Small Cell Lung Cancer Malignancy by Activating the Akt-Mammalian Target of Rapamycin (mTOR) Signaling Pathway.

Content Provider	Europe PMC
Author	Zhang, Wenhua Shao, Xueqian
Copyright Year	2016
Abstract	BackgroundLung cancer is one of the leading causes of cancer mortalities worldwide, and non-small cell lung cancer (NSCLC) accounts for the majority of all lung cancer cases. Surgery remains one of the front-line treatment options for NSCLC, but events within the perioperative period were found to affect cancer prognosis, such as anesthesia procedures. Isoflurane, a commonly used volatile anesthetic, enhances the malignant potential of renal, prostate, and ovarian cancer cells, but its effects on NSCLC development have not been previously reported.Material/MethodsCCK-8 and MTT cell proliferation assays were used to analyze NSCLC cell proliferation. Metastatic ability was examined by wound healing and transwell assays. We used Western blot analysis to study the mechanism of effect of Isoflurane in NSCLC development.ResultsWe demonstrated that isoflurane promotes proliferation, migration and invasiveness of NSCLC cells, as well as upregulation of the Akt-mTOR signaling pathway in NSCLC cells. Pharmacological inhibition of Akt-mTOR signaling abolished the ability of isoflurane to promote proliferation, migration, and invasion of NSCLC cells, indicating that isoflurane promotes NSCLC cell malignancy by activating the Akt-mTOR signaling pathway.ConclusionsIsoflurane promotes NSCLC proliferation, migration and invasion by activating the Akt-mTOR signaling pathway.
ISSN	12341010
Journal	Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
Volume Number	22
PubMed Central reference number	PMC5142580
PubMed reference number	27897153
e-ISSN	16433750
DOI	10.12659/msm.898434
Language	English
Publisher	International Scientific Literature, Inc.
Publisher Date	2016-11-29
Access Restriction	Open
Rights License	This work is licensed under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) © Med Sci Monit, 2016
Subject Keyword	Carcinoma, Non-Small-Cell Lung Isoflurane Proto-Oncogene Proteins c-akt TOR Serine-Threonine Kinases
Content Type	Text
Resource Type	Article
Subject	Medicine

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