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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Samoila, Olguta C. Carter, Angela M. Futers, Simon T. Otiman, Gabriela Anghel, Andrei Tamas, Liviu Seclaman, Edward |
| Description | Country affiliation: Romania Author Affiliation: Samoila OC ( Biochemistry Department, University of Medicine and Pharmacy 'Victor Babes', Timisoara, Romania. corsamol@yahoo.com) |
| Abstract | Extracellular superoxide dismutase (EC-SOD) is the main SOD isoform in the arterial wall contributing to cardiovascular defense against oxidative stress by removing the superoxide anion. In our study, the Thr40Ala and Arg213Gly polymorphic variants of the EC-SOD gene (SOD ( 3 )) were investigated for associations with atherosclerosis and other related factors in 144 subjects with significant atheroma (having one, two, or three major coronary arteries with >50% obstruction, and/or peripheral artery lesions, and/or carotid artery stenosis demonstrated by angiography and echography) and in 150 subjects with no significant atheroma. For the Arg213Gly polymorphism, only five heterozygous subjects were found. Although the difference in the genotype distribution for the Thr40Ala polymorphism was not statistically significant between patients with atheroma (AA 49.3%, AG 34.7%, GG 16.0%) and those without significant atheroma (AA 41.3%, AG 43.3%, GG 15.3%), there was an association of the Thr40 allele with diabetes (P = 0.03) and hypertension (P = 0.04). |
| File Format | HTM / HTML |
| ISSN | 00062928 |
| Issue Number | 9-10 |
| Volume Number | 46 |
| e-ISSN | 15734927 |
| Journal | Biochemical Genetics |
| Language | English |
| Publisher | Springer |
| Publisher Date | 2008-10-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Molecular Biology Atherosclerosis Genetics Metabolism Polymorphism, Genetic Superoxide Dismutase Biosynthesis Aged Diabetes Mellitus Female Genetic Variation Genotype Heterozygote Humans Hypertension Male Middle Aged Protein Isoforms Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Genetics Medicine Biochemistry Molecular Biology Ecology, Evolution, Behavior and Systematics |
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