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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Eken, Ayse Erdem, Onur Arsova-Sarafinovska, Zorica Akay, Cemal Sayal, Ahmet Matevska, Nadica Suturkova, Ljubica Erten, Koray Ozgök, Yasar Dimovski, Aleksandar Aydin, Ahmet |
| Spatial Coverage | Turkey |
| Description | Country affiliation: Turkey Author Affiliation: Eken A ( Department of Toxicology, Erciyes University, Faculty of Pharmacy, Kayseri, Turkey.) |
| Abstract | Manganese superoxide dismutase (MnSOD) is the most effective antioxidant enzyme in mitochondria and protects cells from reactive oxygen species-induced oxidative damage. The aim of this study was to investigate the association between MnSOD Ala-9 Val gene polymorphism and prostate cancer (PCa) risk in Turkish men with prostate cancer. 33 patients with PCa and 81 control individuals were included in the study. We observed an association between MnSOD Ala/Ala frequency and a higher PCa risk. In addition, we found that the increased risk of early-onset PCa (under age of 65) in the men homozygous for Ala allele was higher than the men homozygous for Val allele. However, we determined that MnSOD Ala-9 Val genotype was not associated with the aggressiveness of the disease. The results of our study suggest that MnSOD Ala/Ala genotype may influence on early-onset of PCa patients, but no effect on subsequent development of the disease in Turkish men. However, our study has a limitation that is small numbers of individuals for cases and controls. Therefore, the presented study limited our statistical power to fully investigate the gene polymorphism on cancer risk. |
| File Format | HTM / HTML |
| ISSN | 10956670 |
| Issue Number | 3 |
| Volume Number | 27 |
| e-ISSN | 10990461 |
| Journal | Journal of Biochemical and Molecular Toxicology |
| Language | English |
| Publisher | Wiley |
| Publisher Date | 2013-03-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Molecular Biology Discipline Biochemistry Discipline Toxicology Genetic Association Studies Prostatic Neoplasms Genetics Superoxide Dismutase Age Factors Aged Aged, 80 And Over Genotype Humans Male Middle Aged Polymorphism, Single Nucleotide Pathology Risk Factors Turkey Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Health, Toxicology and Mutagenesis Medicine Molecular Biology Biochemistry Toxicology Molecular Medicine |
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