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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Ma, Shanshan He, Zhiyi Zhao, Jie Li, Lei Yuan, Liying Dai, Yingjie Qiu, Jing |
| Spatial Coverage | China |
| Description | Author Affiliation: Ma S ( Department of Neurology, First Affiliated Hospital of China Medical University, Shenyang, 110001, China, haojiemeitao@yahoo.com.cn.) |
| Abstract | Previous studies have shown associations of fetuin-A (alpha2-Heremans-Schmid glycoprotein, AHSG) with various disorders, including insulin resistance, type 2 diabetes mellitus, metabolic syndrome, and atherosclerosis. In this study, genotype and allele frequencies of the rs4918 SNP in the AHSG gene were examined in 380 patients with ischemic stroke and 350 healthy controls from a Northern Han Chinese population via the PCR-RFLP technique. Frequencies of the GG genotype and the G allele in AHSG (rs4918) were significantly higher in patients with ischemic stroke or atherosclerotic cerebral infarction than those in the control group (P < 0.05). Logistic regression analysis demonstrated the significance of rs4918 in these patients, after adjustment for confounding factors (P < 0.05). These findings suggest that rs4918 SNPs of the AHSG gene are associated with a risk for ischemic stroke in a Northern Han Chinese population. |
| File Format | HTM / HTML |
| ISSN | 00062928 |
| Issue Number | 11-12 |
| Volume Number | 51 |
| e-ISSN | 15734927 |
| Journal | Biochemical Genetics |
| Language | English |
| Publisher | Springer |
| Publisher Date | 2013-12-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Molecular Biology Cerebral Infarction Genetics Gene Frequency Genetic Predisposition To Disease Polymorphism, Single Nucleotide Stroke Alpha-2-hs-glycoprotein Aged China Female Genotype Humans Male Middle Aged Polymorphism, Restriction Fragment Length Regression Analysis Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Genetics Medicine Biochemistry Molecular Biology Ecology, Evolution, Behavior and Systematics |
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